Back to Search
Start Over
Retinal thinning and brain atrophy in early MS and CIS
- Source :
- Acta neurologica ScandinavicaREFERENCES. 142(5)
- Publication Year :
- 2020
-
Abstract
- BACKGROUND Optical coherence tomography (OCT) could be complementary to magnetic resonance imaging (MRI) of the brain in monitoring course of multiple sclerosis (MS) and clinically isolated syndrome (CIS). Thinning of neurons in ganglion cell-inner plexiform layer (GCIPL) measured by OCT is assumed to be associated with brain atrophy. OBJECTIVES To evaluate association of GCIPL with brain parameters detected by quantitative MRI (qMRI) and MR-spectroscopy (MRS) in early MS and CIS. METHODS Seventeen newly diagnosed MS and 18 CIS patients were prospectively included. The patients were assessed at baseline as well as at 1 year follow-up by OCT, qMRI and MRS. Brain parenchymal and myelin volumes (BPV, MYV respectively) and the corresponding fractions (BPF, MYF) were measured with qMRI. Metabolites including myo-inositol (myo-Ins) were measured in the normal-appearing white matter (NAWM) using MRS. T-tests and ANOVA were used to analyze group differences, and linear regression models to evaluate association of GCIPL with BPV, MYV and myo-Ins after correlation analysis. RESULTS Disease activity reflected by lesions on MRI and presence of CSF oligoclonal IgG bands were more prominent in MS compared to CIS. GCIPL, BPV, MYV, BPF and MYF were reduced, while concentration of myo-Ins was increased in MS compared to CIS. Follow-up showed consistency of thinner GCIPL in MS compared to CIS. GCIPL thinning correlated with reduced BPV and MYV (P
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Neurology
Magnetic Resonance Spectroscopy
Multiple Sclerosis
Adolescent
Neuroimaging
Retina
White matter
03 medical and health sciences
Young Adult
0302 clinical medicine
Atrophy
Medicine
Humans
030212 general & internal medicine
Retinal thinning
Clinically isolated syndrome
medicine.diagnostic_test
business.industry
Multiple sclerosis
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Ganglion
medicine.anatomical_structure
Early Diagnosis
Disease Progression
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Tomography, Optical Coherence
Demyelinating Diseases
Subjects
Details
- ISSN :
- 16000404
- Volume :
- 142
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Acta neurologica ScandinavicaREFERENCES
- Accession number :
- edsair.doi.dedup.....08d45396baa8654d34d1d5f50ad80d98