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Antibody persistence six years after two doses of combined hepatitis A and B vaccine
- Source :
- Vaccine. 28:2222-2226
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Persistent immunity to hepatitis A and hepatitis B antibodies six years after vaccination of adolescents (aged 12-15 years) with a combined hepatitis A and B (HAB) vaccine following a 0, 6 month or a 0, 12 month schedule was assessed. Yearly (Year-2-6) serum samples were tested for anti-HAV and anti-HBs using EIA. Subjects with anti-HBs concentrations10 mIU/mL (14/23) at Year-5 or Year-6, received an additional HBV vaccine dose approximately 12 months after Year-6. Blood samples were collected pre-booster and 1 month post-booster to assess booster response. 240 subjects were vaccinated in the study; at Year-6, data were available from 88 subjects. At that time 84.8% (39/46; 0, 6 month) and 92.9% (39/42; 0, 12 month) of subjects had anti-HBs concentrationsor = 10 mIU/mL. All but one of the 14 boosted subjects responded to the additional HBV vaccine dose with anti-HBs concentrationsor = 100 mIU/mL. All seroconverted subjects who returned at Year-6 were seropositive for anti-HAV. Simplification, reduced number of doses and similar long-term persistence of immunity make the 0, 6 month and 0, 12 month schedule preferable for immunization against HAV/HBV in this population.
- Subjects :
- Male
Time Factors
Adolescent
Hepatitis A vaccine
Immunization, Secondary
Hepatitis A Antibodies
Young Adult
Blood serum
Humans
Medicine
Hepatitis B Vaccines
Vaccines, Combined
Hepatitis B Antibodies
Seroconversion
Child
Hepatitis A Vaccines
General Veterinary
General Immunology and Microbiology
biology
business.industry
Vaccination
Public Health, Environmental and Occupational Health
virus diseases
Hepatitis A
Hepatitis B
medicine.disease
digestive system diseases
Infectious Diseases
Immunology
biology.protein
Molecular Medicine
Female
Antibody
business
Viral hepatitis
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....08d3b7b012f37b407d00eb438b07105e