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Results of a prospective thyroid ultrasound screening program in adenomatous polyposis patients
- Source :
- The American Journal of Surgery. 208:764-769
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Background Patients with adenomatous polyposis may be at increased risk for developing thyroid cancer (TC). However, screening guidelines for TC in these patients are not well established. Methods Patients with a diagnosis of familial adenomatous polyposis, attenuated familial adenomatous polyposis, and gene mutation-negative adenomatous polyposis enrolled in our Hereditary Colorectal Cancer Family Registry were eligible for a screening thyroid ultrasound (US). Findings were reviewed by the study endocrinologist and intervention and/or follow-up determined. Results Fifty patients underwent screening thyroid US. Thirty-four (68%) patients had abnormal findings on US, including 27 (79%) with thyroid nodules. In 7 patients, US-detected thyroid nodules met established criteria for fine-needle aspiration. Of the 6 patients who underwent fine-needle aspiration, 2 (4%) were diagnosed with papillary TC. Both of these patients were female. Conclusions A large proportion of adenomatous polyposis patients will have abnormal results on thyroid US, including suspicious-appearing thyroid nodules that when biopsied are malignant. Female patients have an apparently greater risk of developing TC. Polyposis patients, especially women, should be offered participation in a thyroid US screening program.
- Subjects :
- Adult
Male
Oncology
Thyroid nodules
medicine.medical_specialty
Adolescent
Adenomatous polyposis coli
Colorectal cancer
Biopsy, Fine-Needle
Thyroid Gland
Gastroenterology
Familial adenomatous polyposis
Young Adult
Risk Factors
Internal medicine
medicine
Humans
Prospective Studies
Registries
Thyroid Neoplasms
Thyroid Nodule
Child
Prospective cohort study
Thyroid cancer
Early Detection of Cancer
Ultrasonography
biology
business.industry
Carcinoma
Thyroid
General Medicine
Middle Aged
medicine.disease
Carcinoma, Papillary
medicine.anatomical_structure
Adenomatous Polyposis Coli
Attenuated familial adenomatous polyposis
Thyroid Cancer, Papillary
biology.protein
Female
Surgery
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00029610
- Volume :
- 208
- Database :
- OpenAIRE
- Journal :
- The American Journal of Surgery
- Accession number :
- edsair.doi.dedup.....08bf369168941657e31a2834aaeddca6