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Mitochondrial DNA Haplogroup Related to the Prevalence of Helicobacter pylori
- Source :
- Cells, Cells, Vol 10, Iss 2482, p 2482 (2021), Volume 10, Issue 9
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Mitochondria are essential organelles that are not only responsible for energy production but are also involved in cell metabolism, calcium homeostasis, and apoptosis. Targeting mitochondria is a key strategy for bacteria to subvert host cells’ physiology and promote infection. Helicobacter (H.) pylori targets mitochondria directly. However, mitochondrial genome (mtDNA) polymorphism (haplogroup) is not yet considered an important factor for H. pylori infection. Here, we clarified the association of mitochondrial haplogroups with H. pylori prevalence and the ability to perform damage. Seven mtDNA haplogroups were identified among 28 H. pylori-positive subjects. Haplogroup B was present at a higher frequency and haplotype D at a lower one in the H. pylori population than in that of the H. pylori-negative one. The fibroblasts carrying high-frequency haplogroup displayed a higher apoptotic rate and diminished mitochondrial respiration following H. pylori infection. mtDNA mutations were accumulated more in the H. pylori-positive population than in that of the H. pylori-negative one in old age. Among the mutations, 57% were located in RNA genes or nonsynonymous protein-coding regions in the H. pylori-positive population, while 35% were in the H. pylori-negative one. We concluded that gastric disease caused by Helicobacter virulence could be associated with haplogroups and mtDNA mutations.
- Subjects :
- Male
Mitochondrial DNA
haplogroup
QH301-705.5
Population
Stomach Diseases
Biology
Mitochondrion
DNA, Mitochondrial
Haplogroup
Article
susceptibility
Helicobacter Infections
Republic of Korea
Prevalence
Humans
Helicobacter
Biology (General)
education
Aged
Genetics
education.field_of_study
Helicobacter pylori
Haplotype
General Medicine
Fibroblasts
Middle Aged
biology.organism_classification
bacterial infections and mycoses
Haplotypes
mitochondrial genome
Gastric Mucosa
Genome, Mitochondrial
Mutation
Female
Human mitochondrial DNA haplogroup
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....08bac117d2a5553aa2d0693b02a87506