Genetic Susceptibility in Dupuytren’s Disease: Lack of Association of a Novel Transforming Growth Factor β2Polymorphism in Dupuytren’s Disease

The genes involved in the pathogenesis of Dupuytren’s disease have yet to be identified. In this study, we tested for an association between Dupuytren’s disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ2gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ2allele frequency distributions between cases and controls for the TGFβ2polymorphism.