Study on the Solubilization of Sparfloxacin by Aqueous Cosolvent and Micellar Solutions

The effect of ethanol, glycerol, propylene glycol, polysorbate-80 and sodium lauryl sulfate on the aqueous solubility of sparfloxacin was studied. It was found that all these substances increase the aqueous solubility of the drug. Of the solubilizing agents used, sodium lauryl sulfate was observed to be the most effective. The increase was in the following order: sodium lauryl sulfate > polysorbate-80 > propylene glycol > glycerol.