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Downstaging Without Complete Pathologic Response After Neoadjuvant Treatment Improves Cancer Outcomes for cIII but not cII Rectal Cancers
- Source :
- Annals of Surgical Oncology. 17:1758-1766
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- The aim of this study was to evaluate whether downstaging impacts prognosis in patients with cII versus cIII rectal cancer. We identified from our colorectal cancer database 295 patients with primary cII and cIII rectal cancer staged by CT and ERUS/MRI who received 5-FU-based chemoradiation followed by R0 surgery after a median interval of 7 weeks during 1997–2007. The median radiotherapy dose was 5040 cGy. We excluded 58 patients with pathologic complete response (pCR) and compared among the remaining 162 patients pathologic downstaging (cII to ypI, cIII to ypII or ypI) versus no pathologic downstaging (c stage ≤ yp stage). Outcomes evaluated were 5-year overall survival, 3-year cancer-specific survival, disease-free survival, overall recurrence, local recurrence, and distant recurrence. The median age was 58 years and median follow-up was 48 months. Patients with downstaging versus no downstaging were statistically comparable with respect to demographics, chemoradiation regimen, interval time between neoadjuvant chemoradiation and surgery, tumor distance from anal verge, surgical procedures performed, and follow-up time. With the exception of local recurrence rates, downstaging resulted in significantly improved cancer outcomes for cIII but not cII. Downstaging without pCR is a significant prognostic factor for patients with stage cIII rectal cancer. Tumor response to neoadjuvant chemoradiation should be taken into account when defining the optimal adjuvant chemotherapy regimen for patients with cIII rectal cancer.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
Surgical oncology
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Stage (cooking)
Survival rate
Neoadjuvant therapy
Aged
Neoplasm Staging
Aged, 80 and over
Chemotherapy
business.industry
Cancer
Radiotherapy Dosage
Middle Aged
medicine.disease
Combined Modality Therapy
Neoadjuvant Therapy
Survival Rate
Regimen
Treatment Outcome
Chemotherapy, Adjuvant
Lymphatic Metastasis
Female
Surgery
Neoplasm Recurrence, Local
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 15344681 and 10689265
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Annals of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....08ab4b2f3781a3a89d9596997750428b