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c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice
- Source :
- European journal of immunologyReferences. 51(8)
- Publication Year :
- 2021
-
Abstract
- The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple points of the stepwise developmental pathway. Here, we found that the thymic Treg defect in c-Rel-deficient (cRel-/- ) mice is quantitative, not qualitative, based on analyses of TCR repertoire and TCR signaling strength. However, these parameters are altered in the thymic Treg-precursor population, which is also markedly diminished in cRel-/- mice. Moreover, c-Rel governs the transcriptional programme of both thymic and peripheral Tregs, controlling a core of genes involved with immune signaling, and separately in the periphery, cell cycle progression. Last, the immune suppressive function of peripheral cRel-/- tTregs is diminished in a lymphopenic model of T cell proliferation and is associated with decreased stability of Foxp3 expression. Collectively, we show that c-Rel is a transcriptional regulator that controls multiple aspects of Treg development, differentiation, and function via distinct mechanisms. ispartof: EUROPEAN JOURNAL OF IMMUNOLOGY vol:51 issue:8 pages:2006-2026 ispartof: location:Germany status: published
- Subjects :
- CLONAL DELETION
0301 basic medicine
T cell
Cellular differentiation
NF-KAPPA-B
DISTINCT ROLES
Immunology
Population
EXHIBIT DEFECTS
Regulator
chemical and pharmacologic phenomena
Lymphocyte proliferation
Thymus Gland
Biology
Thymic development
Lymphocyte Activation
T-Lymphocytes, Regulatory
Clonal deletion
c-Rel
03 medical and health sciences
Mice
0302 clinical medicine
Cell cycle progression
medicine
Immunology and Allergy
Animals
TRANSCRIPTION FACTOR
education
Transcription factor
GENE-EXPRESSION
Mice, Knockout
education.field_of_study
Science & Technology
TGF-BETA
hemic and immune systems
Cell Differentiation
Regulatory T cells
Proto-Oncogene Proteins c-rel
Cell biology
LYMPHOCYTE-PROLIFERATION
Mice, Inbred C57BL
SIGNAL STRENGTH
CYCLE PROGRESSION
030104 developmental biology
medicine.anatomical_structure
REL
Life Sciences & Biomedicine
030215 immunology
Subjects
Details
- ISSN :
- 15214141 and 00142980
- Volume :
- 51
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- European journal of immunologyReferences
- Accession number :
- edsair.doi.dedup.....08a99c971d5e8f71bac913ad00eb5020