Back to Search
Start Over
An assessment of tonometry and regional splanchnic blood flow during aortic cross-clamping in the pig
- Source :
- Anaesthesia and intensive care. 24(1)
- Publication Year :
- 1996
-
Abstract
- We aimed to evaluate the tonometer in the assessment of gastrointestinal ischaemia induced by an infrarenal aortic cross-clamp. Nine anaesthetized pigs were cannulated for haemodynamic monitoring and radionuclide labelled microsphere (RLM) injection. Gastric and sigmoid tonometers were positioned. After haemodynamic stabilization an infrarenal aortic cross-clamp was applied. Animals were sacrificed at the completion of the study and tissue sampled from the stomach and sigmoid colon for regional blood flow measurements. Measurements were made pre-clamp, post-clamp, pre-release and post-release. Haemodynamic parameters, gastric intramucosal pH (pHi) and blood flow did not change throughout the experiment. Arterial pH increased during cross-clamp and returned to baseline post-release. Arterial bicarbonate fell post release. Sigmoid blood flow fell during cross-clamp. The sigmoid pHi fall, delayed until pre-release, remained low post-release. Although there was a consistent fall in sigmoid pHi, 63% of post-clamp values remained within the baseline range. We conclude that maintaining haemodynamic parameters around baseline values resulted in maintenance of gastric mucosal perfusion as indicated by a steady gastric pHi. However, below the aortic cross-clamp, delay between change in sigmoid colon blood flow and change in pHi and wide variation in sigmoid pHi limits the value of an individual pHi measurement in detecting ischaemia.
- Subjects :
- medicine.medical_specialty
Swine
Ischemia
Hemodynamics
Critical Care and Intensive Care Medicine
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine.artery
Pressure
Medicine
Animals
030212 general & internal medicine
Splanchnic Circulation
Aorta
business.industry
Stomach
Sigmoid colon
030208 emergency & critical care medicine
Blood flow
Hydrogen-Ion Concentration
medicine.disease
Constriction
digestive system diseases
Microspheres
Surgery
Bicarbonates
Anesthesiology and Pain Medicine
medicine.anatomical_structure
Gastric Mucosa
Cardiology
business
Splanchnic
Perfusion
Subjects
Details
- ISSN :
- 0310057X
- Volume :
- 24
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Anaesthesia and intensive care
- Accession number :
- edsair.doi.dedup.....0898c84a4f3a3097b304995eab451f26