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Architecture of the Mammalian Golgi
- Source :
- Cold Spring Harbor Perspectives in Biology. 3:a005181-a005181
- Publication Year :
- 2011
- Publisher :
- Cold Spring Harbor Laboratory, 2011.
-
Abstract
- Since its first visualization in 1898, the Golgi has been a topic of intense morphological research. A typical mammalian Golgi consists of a pile of stapled cisternae, the Golgi stack, which is a key station for modification of newly synthesized proteins and lipids. Distinct stacks are interconnected by tubules to form the Golgi ribbon. At the entrance site of the Golgi, the cis-Golgi, vesicular tubular clusters (VTCs) form the intermediate between the endoplasmic reticulum and the Golgi stack. At the exit site of the Golgi, the trans-Golgi, the trans-Golgi network (TGN) is the major site of sorting proteins to distinct cellular locations. Golgi functioning can only be understood in light of its complex architecture, as was revealed by a range of distinct electron microscopy (EM) approaches. In this article, a general concept of mammalian Golgi architecture, including VTCs and the TGN, is described.
- Subjects :
- Mammals
Endosome
Vesicular-tubular cluster
Endoplasmic reticulum
Golgi Apparatus
COPI
Golgi apparatus
COP-Coated Vesicles
Biology
Endoplasmic Reticulum
General Biochemistry, Genetics and Molecular Biology
Cell biology
Mice
Microscopy, Electron
symbols.namesake
symbols
Animals
Humans
Golgi ribbon
Secretory pathway
trans-Golgi Network
Subjects
Details
- ISSN :
- 19430264
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Cold Spring Harbor Perspectives in Biology
- Accession number :
- edsair.doi.dedup.....088deb981b509d9e5c9b7a00d28ed324