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Gene therapy to create biological pacemakers
- Source :
- Medical & biological engineering & computing, 45(2), 167-176. Springer Verlag
- Publication Year :
- 2006
-
Abstract
- Old age and a variety of cardiovascular disorders may disrupt normal sinus node function. Currently, this is successfully treated with electronic pacemakers, which, however, leave room for improvement. During the past decade, different strategies to initiate pacemaker function by gene therapy were developed. In the search for a biological pacemaker, various approaches were explored, including beta(2)-adrenergic receptor overexpression, down regulation of the inward rectifier current, and overexpression of the pacemaker current. The most recent advances include overexpression of bioengineered ion channels and genetically modified stem cells. This review considers the strengths and the weaknesses of the different approaches and discusses some of the different viral vectors currently used.
- Subjects :
- medicine.medical_specialty
Biological pacemaker
Genetic enhancement
Genetic Vectors
Biomedical Engineering
Biology
Mesenchymal Stem Cell Transplantation
Ion Channels
Viral vector
Adenoviridae
Pacemaker potential
Internal medicine
medicine
Humans
Myocytes, Cardiac
Sinoatrial Node
Sinoatrial node
Gene Transfer Techniques
Arrhythmias, Cardiac
Human physiology
Genetic Therapy
Sinus node function
Computer Science Applications
medicine.anatomical_structure
Cardiology
Stem cell
Neuroscience
Subjects
Details
- ISSN :
- 01400118
- Volume :
- 45
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Medicalbiological engineeringcomputing
- Accession number :
- edsair.doi.dedup.....088088d0f13d9e40f02ee45aceec267e