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Elucidation of White Matter Tracts of the Human Amygdala by Detailed Comparison between High-Resolution Postmortem Magnetic Resonance Imaging and Histology
- Source :
- Frontiers in Neuroanatomy
- Publication Year :
- 2017
- Publisher :
- Frontiers Media SA, 2017.
-
Abstract
- The amygdala is one of the anatomical structures that has attracted intensive interest because of its potential involvement in various neuropsychiatric disorders. In recent years, attempts have been made to evaluate the integrity of the axonal connections from and to the amygdala under pathological conditions using MRI. Although the amygdalar pathways have been extensively studied in the past using animal models, the current anatomical references for the human brain are limited to histology-based resources at a small number of slice locations, orientations, and annotations. In this study, we performed high-resolution MRI (250 m) of postmortem samples, followed by serial histology sections. The histology data served as the ground truth to identify amygdalar pathways, and the anatomical delineation of the assigned structures was extended to 3D using the MRI data. We could clearly define the detailed anatomy of the stria terminalis and amygdalofugal pathway, as well as the anatomy of the nearby basal forebrain areas, including the substantia innominata. The results could help us to understand the detailed white matter structures associated with the amygdala and serve as an anatomical reference by which to design and interpret in vivo MRI data.
- Subjects :
- 0301 basic medicine
Neuroscience (miscellaneous)
stria terminalis
Amygdalofugal pathway
histology
White matter
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
medicine
white matter anatomy
Original Research
Basal forebrain
medicine.diagnostic_test
microimaging
amygdalofugal pathway
Substantia innominata
Magnetic resonance imaging
amygdala
Anatomy
Human brain
diffusion tensor imaging
Stria terminalis
030104 developmental biology
medicine.anatomical_structure
Psychology
Neuroscience
030217 neurology & neurosurgery
MRI
Diffusion MRI
Subjects
Details
- ISSN :
- 16625129
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neuroanatomy
- Accession number :
- edsair.doi.dedup.....086898f74c415737dd80721dc1cc27a7
- Full Text :
- https://doi.org/10.3389/fnana.2017.00016