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One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients
- Source :
- Br J Nutr, British Journal of Nutrition, 123(10), 1187-1200, British Journal of Nutrition, 123(10):0007114520000422, 1187-1200. Cambridge University Press, British Journal of Nutrition 123 (2020) 10
- Publication Year :
- 2020
-
Abstract
- B vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- and angiogenesis-related chronic diseases, such as colorectal cancer (CRC). Yet, the role of one-carbon metabolism in inflammation and angiogenesis among CRC patients remains unclear. The objective of this study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed CRC patients (n 238) in the prospective ColoCare Study, Heidelberg. We cross-sectionally analysed associations between twelve B vitamins and one-carbon metabolites and ten inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesised that pyridoxal-5’-phosphate (PLP) is inversely associated with inflammatory biomarkers. We observed that PLP was inversely associated with C-reactive protein (CRP) (r –0·33, Plinear < 0·0001), serum amyloid A (SAA) (r –0·23, Plinear = 0·003), IL-6 (r –0·39, Plinear < 0·0001), IL-8 (r –0·20, Plinear = 0·02) and TNFα (r –0·12, Plinear = 0·045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP (r –0·14), SAA (r –0·14) and TNFα (r –0·15) among CRC patients. Folate catabolite acetyl-para-aminobenzoylglutamic acid (pABG) was positively correlated with IL-6 (r 0·27, Plinear < 0·0001), and pABG was positively correlated with IL-8 (r 0·21, Plinear < 0·0001), indicating higher folate utilisation during inflammation. Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among CRC patients. A better understanding of the role and inter-relation of PLP and other one-carbon metabolites with inflammatory processes among colorectal carcinogenesis and prognosis could identify targets for future dietary guidance for CRC patients.
- Subjects :
- 0301 basic medicine
Oncology
Male
Folate
Nutrition and Disease
Colorectal cancer
Angiogenesis
Medicine (miscellaneous)
Systemic inflammation
chemistry.chemical_compound
0302 clinical medicine
Glutamates
Voeding en Ziekte
FOLIC-ACID SUPPLEMENTATION
Prospective Studies
PYRIDOXAL 5'-PHOSPHATE
OXIDATIVE STRESS
Vitamin B
Tetrahydrofolates
Aged, 80 and over
THIAMINE-DEFICIENCY
RISK
Nutrition and Dietetics
biology
Neovascularization, Pathologic
CRPangiogenesis
Middle Aged
One-carbon metabolism
C-REACTIVE PROTEIN
Vascular endothelial growth factor
Intestines
CATABOLISM
030220 oncology & carcinogenesis
Vitamin B Complex
Female
medicine.symptom
Inflammation Mediators
Colorectal Neoplasms
Adult
medicine.medical_specialty
Amyloid
Adolescent
B vitamins
colorectal cancer
Inflammation
folate
Article
Statistics, Nonparametric
folic acid
03 medical and health sciences
Young Adult
B-vitamins
Folic Acid
Internal medicine
medicine
Biomarkers, Tumor
Humans
Serum amyloid A
Aged
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
C-reactive protein
Interleukin-8
medicine.disease
Carbon
Phosphoric Monoester Hydrolases
ASPIRIN
030104 developmental biology
Cross-Sectional Studies
chemistry
inflammation
PLASMA HOMOCYSTEINE
biology.protein
Linear Models
Vitamin B-6
business
Subjects
Details
- Language :
- English
- ISSN :
- 00071145
- Volume :
- 123
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....0852b029804b1393233e31037405500c