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Inducing iPSCs to Escape the Dish
- Source :
- Cell Stem Cell. 9(2):103-111
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Induced pluripotent stem cells (iPSCs) hold great promise for autologous cell therapies, but significant roadblocks remain to translating iPSCs to the bedside. For example, concerns about the presumed autologous transplantation potential of iPSCs have been raised by a recent paper demonstrating that iPSC-derived teratomas were rejected by syngeneic hosts. Additionally, the reprogramming process can alter genomic and epigenomic states, so a key goal at this point is to determine the clinical relevance of these changes and minimize those that prove to be deleterious. Finally, thus far few studies have examined the efficacy and tumorigenicity of iPSCs in clinically relevant transplantation scenarios, an essential requirement for the FDA. We discuss potential solutions to these hurdles to provide a roadmap for iPSCs to "jump the dish" and become useful therapies.
- Subjects :
- Genetics
Autologous cell
Genome, Human
Induced Pluripotent Stem Cells
Immunity
Cell Biology
Biology
Article
Epigenesis, Genetic
Transplantation
Translational Research, Biomedical
Cell Transformation, Neoplastic
Autologous transplantation
Humans
Molecular Medicine
Induced pluripotent stem cell
Reprogramming
Neuroscience
Subjects
Details
- ISSN :
- 19345909
- Volume :
- 9
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell Stem Cell
- Accession number :
- edsair.doi.dedup.....0851c47e08835d5562aeeb6bd7318d33
- Full Text :
- https://doi.org/10.1016/j.stem.2011.07.006