Detoxication of sodium 35 S-sulphide in the rat

When sodium 35S-sulphide is administered to rats either intraperitoneally, orally or intravenously it is oxidized primarily to inorganic 35S-sulphate which is eventually excreted in the urine. Intravenously administered sulphide has a transient existence in blood and the lack of an accumulative effect of sulphide poisoning is due to the rapid rate of oxidation. The blood is not the principle site of sulphide oxidation in vivo. Sulphide detoxication occurs in both plasma and red cells in vitro by binding to proteins.