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Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid)
- Source :
- Cancer Immunology Immunotherapy. 34:211-220
- Publication Year :
- 1992
- Publisher :
- Springer Science and Business Media LLC, 1992.
-
Abstract
- We have recently begun a phase II trial in patients with osteosarcoma who developed pulmonary metastases during adjuvant chemotherapy or who presented with pulmonary metastases that persisted despite chemotherapy. Eligible patients were rendered free of visible disease by surgery. Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (MTP-PE, CGP 19835A lipid) (2 mg/m2) was infused twice weekly for 3 months. In five patients, a single tumor nodule recurred within 6 weeks after completion of therapy. These lesions were resected and submitted for pathological examination. Tissue specimens obtained after therapy were compared to those obtained before therapy. All the patients showed a histological change in the characteristics of the pulmonary tumors. In three patients, peripheral fibrosis surrounded the tumor and inflammatory cell infiltration and neovascularization were present. This is in contrast to central necrosis, with viable peripheral tumor cells and no inflammatory response observed in lesions resected following chemotherapy. In a fourth case, evidence of early fibrotic changes was found. This and the fifth case showed a change in malignant characteristics, from high grade before liposomal therapy to low grade after therapy. The present study provides evidence for a biological effect of liposomal MTP-PE.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Lung Neoplasms
Adolescent
medicine.medical_treatment
Immunology
Metastasis
Neovascularization
Adjuvants, Immunologic
Fibrosis
medicine
Humans
Immunology and Allergy
Osteosarcoma
Chemotherapy
Lung
business.industry
Phosphatidylethanolamines
Respiratory disease
Immunotherapy
medicine.disease
medicine.anatomical_structure
Oncology
Chemotherapy, Adjuvant
Liposomes
Female
medicine.symptom
business
Acetylmuramyl-Alanyl-Isoglutamine
Subjects
Details
- ISSN :
- 14320851 and 03407004
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Cancer Immunology Immunotherapy
- Accession number :
- edsair.doi.dedup.....083e8a1d14393c32f16f899d9f7ab7b3