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The Expression of Presenilin 1 mRNA in Skin Fibroblasts and Brains from Sporadic Alzheimer’s Disease
- Source :
- Dementia and Geriatric Cognitive Disorders. 11:245-250
- Publication Year :
- 2000
- Publisher :
- S. Karger AG, 2000.
-
Abstract
- We examined the expression of presenilin 1 (PS-1) mRNA in cultured skin fibroblasts taken from living patients with Alzheimer’s disease (AD) and human brains taken postmortem from AD patients by RT-PCR analysis. The donors of fibroblasts consisted of 28 cases with AD and 19 neurological patient without dementia (CTL). The brains came from 17 cases with AD and 23 cases with CTL. We found that PS-1 mRNA levels in skin fibroblasts of AD patients were significantly higher than those of CTL patients (p < 0.0001). Moreover, we found that PS-1 mRNA levels in human brains with AD were significantly higher than in those with CTL (p < 0.0001). These findings suggest that high levels of PS-1 mRNA in AD may play an important role in developing AD and that the examination of PS-1 mRNA in skin fibroblasts may be helpful for the diagnosis of AD.
- Subjects :
- Male
Aging
medicine.medical_specialty
Pathology
Cognitive Neuroscience
Biology
Presenilin
Central nervous system disease
Degenerative disease
Alzheimer Disease
Internal medicine
Gene expression
Presenilin-1
medicine
Humans
RNA, Messenger
Fibroblast
Aged
Skin
Brain Chemistry
Messenger RNA
Reverse Transcriptase Polymerase Chain Reaction
Membrane Proteins
Fibroblasts
medicine.disease
Reverse transcriptase
Psychiatry and Mental health
medicine.anatomical_structure
Endocrinology
Female
Geriatrics and Gerontology
Alzheimer's disease
Subjects
Details
- ISSN :
- 14219824 and 14208008
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Dementia and Geriatric Cognitive Disorders
- Accession number :
- edsair.doi.dedup.....083c9e7f220cb87e530b59725318ee9d