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Primary central nervous system T-cell lymphoma: An analysis from the surveillance, epidemiology, and end results program
- Source :
- Journal of Clinical Neuroscience. 79:74-79
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Primary central nervous system T-cell lymphoma (PCNSTCL) is a rare neoplasm with few data regarding its common features and survival characteristics.To explore the Surveillance, Epidemiology, and End Results 18 (SEER 18) database to determine the epidemiology of PCNSTCL.The SEER 18 registry database was queried to identify patients diagnosed with PCNSTCL from 1973 to 2014 and extract their information. Age-specific rates and Kaplan-Meier overall survival (OS) were calculated. A Cox proportional hazards model was applied to investigate relationships between various demographic/treatment variables and OS.The age-specific incidence rates were higher in the older population (≥60 years). Among 59 PCNSTCL cases from the SEER 18, the mean age at presentation was 55.8 years (SD, ±17.95), with a male predominance (1.36:1.00). The median follow-up was 8 months, and the median OS was 8 months (SE, ±4.162). The 1-, 3-, and 5-year OS was 46.3% [95% CI, 33.4%-59.2%], 32.8% [20.3%-45.3%], and 32.8% [20.3%-45.3%], respectively. Seventeen of the 59 patients survived at last follow-up. Patients 60 years had a greater 3-year OS compared with patients ≥ 60 years (52.6% [33.6%-71.6%] vs 13.9% [1.4%-26.4%]. Multivariate analysis has demonstrated that only age at diagnosis (≥60/60 years) exhibited a significant relationship with OS (HR, 3.495 [1.688-7.235];p = 0.001). Sex (female/male) was observed to have a doubted trend towards significance (HR, 0.487 [0.231-1.030]; p = 0.060).PCNSTCL is generally of poor prognosis but younger age at diagnosis (60 years) predicts a better prognosis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Poor prognosis
Younger age
Adolescent
Lymphoma, T-Cell
Older population
Central Nervous System Neoplasms
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Internal medicine
Epidemiology
medicine
Surveillance, Epidemiology, and End Results
Humans
T-cell lymphoma
Aged
Proportional Hazards Models
Aged, 80 and over
Proportional hazards model
business.industry
Age Factors
General Medicine
Middle Aged
Prognosis
medicine.disease
Lymphoma
Neurology
030220 oncology & carcinogenesis
Female
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
SEER Program
Subjects
Details
- ISSN :
- 09675868
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....0813b2f12721056b3d07b3caae073017
- Full Text :
- https://doi.org/10.1016/j.jocn.2020.07.020