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Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats
- Source :
- Behavioural Brain Research, 233(2), 322-325. Elsevier Science
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- The majority of patients with panic disorder express a fearful sensation when encountered with panic-related cues. A subpopulation of GABAergic interneurons in the hippocampus has been demonstrated in the regulation of behavioural learning, especially during the contextual fear-conditioning. Here, we examined the influence of panic/fear response induced by deep brain stimulation (DBS) of the periaqueductal gray on these hippocampal parvalbumin-positive interneurons. We found that fear-like behaviour did not change the number of c-Fos immunoreactive and parvalbumin-positive cells. However, a remarkable decrease of c-Fos and parvalbumin co-localization was shown in the hippocampal regions when compared to non-stimulated sham animals. In line with previous studies, our results support the hypothesis that GABAergic regulation resulted in enhanced behavioural reactivity to fear conditioning. In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour. (c) 2012 Elsevier B.V. All rights reserved.
- Subjects :
- Male
Deep brain stimulation
medicine.medical_treatment
Periaqueductal gray
Stimulation
Hippocampal formation
Hippocampus
Behavioral Neuroscience
Interneurons
mental disorders
medicine
Animals
ANXIETY
Fear conditioning
Rats, Wistar
gamma-Aminobutyric Acid
Parvalbumin
CONSOLIDATION
biology
musculoskeletal, neural, and ocular physiology
MEMORY
ESCITALOPRAM
Panic
Immobility Response, Tonic
Fear
Electric Stimulation
PANIC DISORDER
Rats
MODEL
Parvalbumins
nervous system
Exploratory Behavior
biology.protein
GABAergic
medicine.symptom
Psychology
Proto-Oncogene Proteins c-fos
RECEPTOR-BINDING
Neuroscience
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 233
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....08121efb4193ef48160035def917bc2c
- Full Text :
- https://doi.org/10.1016/j.bbr.2012.05.029