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Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats

Authors :
Yasin Temel
Arjan Blokland
Lee Wei Lim
School of Biological Sciences
Neuropsychology & Psychopharmacology
RS: FPN NPPP II
Source :
Behavioural Brain Research, 233(2), 322-325. Elsevier Science
Publication Year :
2012
Publisher :
Elsevier BV, 2012.

Abstract

The majority of patients with panic disorder express a fearful sensation when encountered with panic-related cues. A subpopulation of GABAergic interneurons in the hippocampus has been demonstrated in the regulation of behavioural learning, especially during the contextual fear-conditioning. Here, we examined the influence of panic/fear response induced by deep brain stimulation (DBS) of the periaqueductal gray on these hippocampal parvalbumin-positive interneurons. We found that fear-like behaviour did not change the number of c-Fos immunoreactive and parvalbumin-positive cells. However, a remarkable decrease of c-Fos and parvalbumin co-localization was shown in the hippocampal regions when compared to non-stimulated sham animals. In line with previous studies, our results support the hypothesis that GABAergic regulation resulted in enhanced behavioural reactivity to fear conditioning. In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour. (c) 2012 Elsevier B.V. All rights reserved.

Details

ISSN :
01664328
Volume :
233
Database :
OpenAIRE
Journal :
Behavioural Brain Research
Accession number :
edsair.doi.dedup.....08121efb4193ef48160035def917bc2c
Full Text :
https://doi.org/10.1016/j.bbr.2012.05.029