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Left Ventricular Hypertrophy and Insulin Resistance in Adults from an Urban Community in the Gambia: Cross-Sectional Study
- Source :
- PLoS ONE, Vol 9, Iss 4, p e93606 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Objective To determine the association between left ventricular hypertrophy and insulin resistance in Gambians. Design Cross-sectional study. Setting Outpatient clinics of Royal Victoria Teaching Hospital and Medical Research Council Laboratories in Banjul. Participants Three hundred and sixteen consecutive patients were enrolled from outpatient clinics. The data of 275 participants (89 males) were included in the analysis with a mean (± standard deviation) age of 53.7 (±11.9) years. Interventions A questionnaire was filled and anthropometric measurements were taken. 2-D guided M-mode echocardiography, standard 12-1ead electrocardiogram, fasting insulin and the oral glucose tolerance test were performed. Main Outcome Measures The Penn formula was used to determine the left ventricular mass index, 125 g/m2 in males and 110 g/m2 in females as the cut-off for left ventricular hypertrophy. Using the fasting insulin and fasting glucose levels, the insulin resistance was estimated by the homeostatic model assessment formula. Logistic regression analysis was used to determine the association between left ventricular hypertrophy and insulin resistance. Results The mean Penn left ventricular mass index was 119.5 (±54.3) and the prevalence of Penn left ventricular mass index left ventricular hypertrophy was 41%. The mean fasting glucose was 5.6 (±2.5) mmol/l, fasting insulin was 6.39 (±5.49) μU/ml and insulin resistance was 1.58 (±1.45). There was no association between Penn left ventricular mass index left ventricular hypertrophy and log of insulin resistance in univariate (OR = 0.98, 95% CI = 0.80 – 1.19, p = 0.819) and multivariate logistic regression (OR = 0.93, 95% CI = 0.76–1.15, p = 0.516) analysis. Conclusion No association was found in this study between left ventricular hypertrophy and insulin resistance in Gambians and this does not support the suggestion that insulin is an independent determinant of left ventricular hypertrophy in hypertensives.
- Subjects :
- Male
Urban Population
medicine.medical_treatment
lcsh:Medicine
Blood Pressure
Pathology and Laboratory Medicine
Left ventricular hypertrophy
Biochemistry
Vascular Medicine
Diagnostic Radiology
Electrocardiography
Endocrinology
Residence Characteristics
Ultrasound Imaging
Medicine and Health Sciences
Insulin
Outpatient clinic
Cardiovascular Imaging
lcsh:Science
Glucose tolerance test
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Middle Aged
Cardiovascular Diseases
Echocardiography
Hypertension
Homeostatic model assessment
Cardiology
Female
Gambia
Hypertrophy, Left Ventricular
Anatomy
Cardiomyopathies
Research Article
Adult
medicine.medical_specialty
Endocrine System
Insulin resistance
Diagnostic Medicine
Internal medicine
Diabetes mellitus
medicine
Humans
Aged
Diabetic Endocrinology
business.industry
lcsh:R
Biology and Life Sciences
Glucose Tolerance Test
medicine.disease
Hormones
Cross-Sectional Studies
Anatomical Pathology
lcsh:Q
Insulin Resistance
business
Body mass index
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....080ecf273cd5816cfd6728f954116dde