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24-hour glucose profiles on diets varying in protein content and glycemic index
- Source :
- Nutrients, Vol 6, Iss 8, Pp 3050-3061 (2014), Nutrients, Nutrients; Volume 6; Issue 8; Pages: 3050-3061, Nutrients, 6(8), 3050-3061. Multidisciplinary Digital Publishing Institute (MDPI)
- Publication Year :
- 2014
- Publisher :
- Multidisciplinary Digital Publishing Institute (MDPI), 2014.
-
Abstract
- Evidence is increasing that the postprandial state is an important factor contributing to the risk of chronic diseases. Not only mean glycemia, but also glycemic variability has been implicated in this effect. In this exploratory study, we measured 24-h glucose profiles in 25 overweight participants in a long-term diet intervention study (DIOGENES study on Diet, Obesity and Genes), which had been randomized to four different diet groups consuming diets varying in protein content and glycemic index. In addition, we compared 24-h glucose profiles in a more controlled fashion, where nine other subjects followed in random order the same four diets differing in carbohydrate content by 10 energy% and glycemic index by 20 units during three days. Meals were provided in the lab and had to be eaten at fixed times during the day. No differences in mean glucose concentration or glucose variability (SD) were found between diet groups in the DIOGENES study. In the more controlled lab study, mean 24-h glucose concentrations were also not different. Glucose variability (SD and CONGA1), however, was lower on the diet combining a lower carbohydrate content and GI compared to the diet combining a higher carbohydrate content and GI. These data suggest that diets with moderate differences in carbohydrate content and GI do not affect mean 24-h or daytime glucose concentrations, but may result in differences in the variability of the glucose level in healthy normal weight and overweight individuals.
- Subjects :
- Blood Glucose
Male
Overweight
glycemic index
glycemic load
mean 24-h glucose concentration
glucose variability
continuous glucose monitoring
Body Mass Index
TABLES
COMPOSITE BREAKFAST MEALS
Meals
Nutrition and Dietetics
Cross-Over Studies
Middle Aged
Postprandial Period
INSULIN
Glycemic index
Postprandial
Female
Dietary Proteins
medicine.symptom
lcsh:Nutrition. Foods and food supply
Adult
medicine.medical_specialty
Adolescent
lcsh:TX341-641
DEPENDENT DIABETES-MELLITUS
Biology
Article
Young Adult
Animal science
Internal medicine
CARBOHYDRATE
Glycemic load
medicine
Dietary Carbohydrates
Humans
LOAD
Glycemic
Body Weight
Carbohydrate
medicine.disease
Crossover study
Obesity
Dietary Fats
Body Height
Diet
Endocrinology
Food Science
RESPONSES
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 6
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....08087435e52394dc51d86bcd0fd6c17d