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Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHARTā1) trial design
- Source :
- European Journal of Heart Failure
- Publication Year :
- 2015
- Publisher :
- John Wiley & Sons, Ltd, 2015.
-
Abstract
- Aims Cardiopoiesis is a conditioning programme that aims to upgrade the cardioregenerative aptitude of patient-derived stem cells through lineage specification. Cardiopoietic stem cells tested initially for feasibility and safety exhibited signs of clinical benefit in patients with ischaemic heart failure (HF) warranting definitive evaluation. Accordingly, CHART-1 is designed as a large randomized, sham-controlled multicentre study aimed to validate cardiopoietic stem cell therapy. Methods Patients (n = 240) with chronic HF secondary to ischaemic heart disease, reduced LVEF (
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Ischaemic cardiomyopathy
medicine.medical_treatment
Trial Design
Myocardial Ischemia
030204 cardiovascular system & hematology
Cardiopoiesis
Mesenchymal Stem Cell Transplantation
Regenerative medicine
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Regeneration
Adverse effect
Heart Failure
Ejection fraction
Stem cell
Focus Issue on Cardiac Regeneration
business.industry
Stem Cells
Heart
Stem-cell therapy
medicine.disease
Clinical trial
Catheter
030104 developmental biology
Heart failure
Epidemiologic Research Design
Chronic Disease
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 18790844 and 13889842
- Volume :
- 18
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- European Journal of Heart Failure
- Accession number :
- edsair.doi.dedup.....07e64a007a1ec4308262f28a589003f8