Back to Search
Start Over
The role of microRNAs in the pathogenesis of pituitary tumors
- Source :
- Frontiers in Bioscience. 21:1-7
- Publication Year :
- 2016
- Publisher :
- IMR Press, 2016.
-
Abstract
- Pituitary tumors, the most common intracranial tumors, lead to serious morbidity through the inappropriate secretion of pituitary hormones. The anomalous expression of microRNAs (miRNAs), which have a crucial status in the development and function of pituitary gland, promotes the tumorigenesis of hypothalamic-pituitary axis-related pituitary tumors. This mainly leads to alterations in the function of the hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis and hypothalamic-pituitary-growth hormone. In the tumorigenesis of pituitary tumors, miRNAs have complex roles. They can induce cell cycle arrest, inhibiting cell proliferation and inducing apoptosis via different pathways; however, they also promote the occurrence of pituitary tumors through direct interactions with transcription factors. This review summarizes recent progress in the study of miRNAs on the pathogenesis of pituitary tumors.
- Subjects :
- 0301 basic medicine
Pituitary gland
Cell cycle checkpoint
030102 biochemistry & molecular biology
business.industry
Pituitary tumors
Bioinformatics
medicine.disease
medicine.disease_cause
Pathogenesis
MicroRNAs
03 medical and health sciences
medicine.anatomical_structure
microRNA
Humans
Medicine
Pituitary Neoplasms
business
Carcinogenesis
Transcription factor
Cell Proliferation
Hormone
Subjects
Details
- ISSN :
- 10934715 and 10939946
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Frontiers in Bioscience
- Accession number :
- edsair.doi.dedup.....07dc83d194283268210f098e2416eb6d