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Cytoprotection by propolis ethanol extract of acute absolute ethanol-induced gastric mucosal lesions
- Source :
- The American journal of Chinese medicine. 30(2-3)
- Publication Year :
- 2002
-
Abstract
- Acute p.o. administration of absolute ethanol (1.0 ml/kg) to fasted rats produced extensive necrosis of gastric mucosa. Pretreatment with p.o. administration of propolis ethanol extract (PEE) could effectively and dose-dependently prevent such necrosis. This protective effect is called "cytoprotection." The maximal cytoprotective effect against absolute ethanol (AE)-induced gastric mucosal lesion was observed 1 hour after PEE administration. A gross examination of the gastric mucosa showed a marked improvement in groups receiving PEE. In order to further investigate the gastric protective mechanism of PEE, lipid peroxidation (LPO) levels in vivo and in vitro were estimated. PEE exhibited dose-dependent superoxide scavenging activity and antioxidant effects on AE-induced LPO in rat gastric mucosal homogenates. It was concluded that the gastric protective mechanism of PEE was due, at least in part, to its ability to inhibit LPO, and hence indirectly protect the gastric mucosa from oxidative stress.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Antioxidant
Necrosis
medicine.medical_treatment
Administration, Oral
Pharmacology
medicine.disease_cause
Antioxidants
Propolis
Lipid peroxidation
chemistry.chemical_compound
Oral administration
medicine
Gastric mucosa
Animals
Stomach Ulcer
Rats, Wistar
Dose-Response Relationship, Drug
Ethanol
business.industry
Plant Extracts
Stomach
General Medicine
Anti-Ulcer Agents
Cytoprotection
Rats
medicine.anatomical_structure
Complementary and alternative medicine
chemistry
Gastric Mucosa
Lipid Peroxidation
medicine.symptom
business
Oxidative stress
Phytotherapy
Subjects
Details
- ISSN :
- 0192415X
- Volume :
- 30
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- The American journal of Chinese medicine
- Accession number :
- edsair.doi.dedup.....07d63914c28dc5f81bfa8c2d4002115d