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Association of amino acid imbalance with the severity of liver fibrosis and esophageal varices
- Source :
- Annals of Hepatology, Vol 12, Iss 3, Pp 471-478 (2013)
- Publication Year :
- 2013
- Publisher :
- Elsevier, 2013.
-
Abstract
- Background. The relationships between the metabolic parameters and the endoscopic findings of esophageal varices have been poorly investigated. We investigated the association of the branched-chain amino acids to tyrosine ratio (BTR) with the severity of liver fibrosis and esophageal varices. Material and methods. We studied hepatitis C virus (HCV)-positive chronic liver disease patients who had undergone liver biopsy (n = 149). The relationship between the BTR values and the liver fibrotic stage was investigated. We also studied whether the BTR value was associated with the presence and bleeding risk of varices in patients with HCV-related compensated cirrhosis. Results. The mean values of the BTR decreased with the progression of the fibrosis (METAVIR score: F0-1: 6.40 ± 1.19; F2: 5.85 ± 1.33; F3: 5.24 ± 0.97, F4: 4.78 ± 1.14). In the 58 patients with HCVrelated compensated cirrhosis, the mean values of the BTR decreased with the severity of varices (patients without varices: 5.01 ± 1.15, patients with a low-risk varices: 4.42 ± 1.06, patients with a high-risk varices: 3.86 ± 1.02). The BTR value was significantly lower in the patients with varices than in those without varices (4.17 ± 1.07 vs. 5.01 ± 1.15, P < 0.01). The BTR value was also significantly lower in the patients with a high risk of hemorrhage than in those with a low risk (3.86 ± 1.02 vs. 4.78 ± 1.14, P < 0.01). Furthermore, the BTR value was the most significantly different parameter, with the smallest P-value among all the factors examined, including the platelet count and albumin level. Conclusion. A decreased BTR value was found to be associated with the progression of liver fibrosis and severity of varices.
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Biopsy
Branched-chain amino acids to Tyr ratio
Specialties of internal medicine
Chronic liver disease
Esophageal and Gastric Varices
Gastroenterology
Risk Assessment
Severity of Illness Index
Young Adult
Esophageal varices
Fibrosis
Risk Factors
Internal medicine
medicine
Humans
Portal hypertension
Aged
Aged, 80 and over
Analysis of Variance
Hepatology
medicine.diagnostic_test
business.industry
General Medicine
Biomarker
Middle Aged
medicine.disease
Hepatitis C
Metabolism
RC581-951
Liver biopsy
Disease Progression
Tyrosine
Female
Varices
business
Gastrointestinal Hemorrhage
Amino Acids, Branched-Chain
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 16652681
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Annals of Hepatology
- Accession number :
- edsair.doi.dedup.....07cff449c858de74a7e1ae8cea855e36