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Mean platelet volume is a useful parameter: a reproducible routine method using a modified Coulter Thrombocytometer
- Source :
- Platelets. 11:379-387
- Publication Year :
- 2000
- Publisher :
- Informa UK Limited, 2000.
-
Abstract
- The principal physiological function of platelets is to promote haemostasis but they also contribute to thrombosis and atherogenesis. Platelet volume is a marker and possibly a determinant of platelet function in that large platelets are more active than normal sized platelets. Mean platelet volume (MPV), a measure of platelet size, reflects changes in either the level of platelet stimulation or the rate of platelet production. For these reasons, we have developed a sensitive instrument to measure platelet volume, which we believe is more reliable and specific than previously used instruments. It is based on a computer-interfaced Coulter Thrombocytometer and a pulse analyser including a high-speed baseline restorer. We have developed a reproducible method to assay MPV and from the histogram derived the median (MED) and the skewness (SK) values. We have looked at the effects of anticoagulant used and time elapse prior to assay. A normal range has been established for MPV which correlates directly with MED and inversely with SK. The MPV decreases with age but there is no difference between genders. We have demonstrated a negative correlation between whole blood platelet number and MPV and MED, and a direct relationship with the SK of the histogram of the platelet volume.
- Subjects :
- Adult
Blood Platelets
Male
medicine.medical_specialty
Adolescent
Platelet Aggregation
Platelet Function Tests
medicine.drug_class
Sensitivity and Specificity
Statistics, Nonparametric
Sex Factors
Internal medicine
Platelet production
medicine
Humans
Platelet
Mean platelet volume
Child
Normal range
Aged
Cell Size
Whole blood
Electronic Data Processing
Platelet Count
business.industry
Anticoagulant
Age Factors
Large Platelets
Reproducibility of Results
Hematology
General Medicine
Middle Aged
medicine.disease
Thrombosis
Case-Control Studies
Immunology
Cardiology
Female
business
Subjects
Details
- ISSN :
- 13691635 and 09537104
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Platelets
- Accession number :
- edsair.doi.dedup.....07ce47d891a8681ee4d619938ee7fd95