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Association between serum sphingolipids and eudaimonic well-being in white U.S. adults
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Emerging research has linked psychological well-being with many physiological markers as well as morbidity and mortality. In this analysis, the relationship between components of eudaimonic well-being and serum sphingolipids levels was investigated using data from a large national survey of middle-aged American adults (Midlife in the United States). Health behaviors (i.e., diet, exercise, and sleep) were also examined as potential mediators of these relationships. Serum levels of total ceramides - the main molecular class of sphingolipids previously associated with several disease conditions - were inversely linked with environmental mastery. In addition, significant correlations were found between specific ceramide, dihydroceramide, and hexosylceramides species with environmental mastery, purpose in life, and self-acceptance. Using hierarchical regression and mediation analyses, health behaviors appeared to mediate these associations. However, the link between ceramides and environmental mastery was partially independent of health behaviors, suggesting the role of additional mediating factors. These findings point to sphingolipid metabolism as a novel pathway of health benefits associated with psychological well-being. In particular, having a sense of environmental mastery may promote restorative behaviors and benefit health via improved blood sphingolipid profiles.
- Subjects :
- 0301 basic medicine
Quality of life
Adult
Male
Mediation (statistics)
Ceramide
Science
Disease
Ceramides
Article
White People
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Quality of life (healthcare)
Adrenal Cortex Hormones
Psychology
Humans
Obesity
Association (psychology)
Life Style
Internal-External Control
Aged
Dyslipidemias
Aged, 80 and over
Sphingolipids
Multidisciplinary
Depression
Multilevel model
Middle Aged
Sphingolipid
Self Concept
Self Efficacy
United States
030104 developmental biology
chemistry
Well-being
Lipidomics
Hypertension
Personal Autonomy
Medicine
Female
Sleep
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....07c6ba1226806cd210d29222ad813ebc