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Gemcitabine-induced digital ischaemia in a patient with metastatic breast cancer

Authors :
Abdul Moiz Khan
Lubina Arjyal
Lelas Shamaileh
Michael Simon
Source :
BMJ case reports. 15(11)
Publication Year :
2024

Abstract

A woman in her 50s with HER2 (human epidermal growth factor receptor 2) positive, estrogen/progesterone receptor negative, metastatic invasive ductal carcinoma of the breast, presented with acral cyanosis and severe throbbing pain after recent administration of gemcitabine. She was treated with aspirin, heparin, amlodipine, topical nitroglycerin and analgesics. Gemcitabine was discontinued permanently. She had a gradual recovery except for a small necrotic area over the right 4th digit. However, surgical intervention was avoided.

Details

ISSN :
1757790X
Volume :
15
Issue :
11
Database :
OpenAIRE
Journal :
BMJ case reports
Accession number :
edsair.doi.dedup.....07c656a125b22f940deaed0176cc20c0