Additional file 1 of APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia

Additional file 1: Supplementary Figure 1. White matter hyperintensity load among early-stage dementia APOE4 non-carriers relates to worse cognition than APOE4 carriers. In early-stage dementia participants, there was a significant interaction effect between WMH load and APOE4 status on cognition. Increasing white matter hyperintensity load was associated with (A) lower MMSE scores and (B) poorer Color Trails 2 performance in APOE4 non-carriers compared to APOE4 carriers. The solid line refers to APOE4 non-carriers while the dashed line refers to APOE4 carriers. Abbreviations: APOE4, apolipoprotein E4; MMSE, mini-mental state examination; WMH, white matter hyperintensity.