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Radiofrequency catheter ablation and nerve growth factor concentration in humans
- Source :
- Heart Rhythm. 3:1150-1155
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- In animal models, expression of nerve growth factor (NGF) is increased after necrotic myocardial injury. Whether radiofrequency (RF) catheter ablation increases NGF expression in humans is unclear.The purpose of this study was to determine NGF concentrations in the aorta, coronary sinus, and peripheral veins before and after RF ablation in patients.We sampled blood from aorta and either great cardiac vein (group 1, N = 18) or proximal (group 2, N = 20) coronary sinus before and after RF ablation. In group 3 (N = 21), peripheral venous blood was sampled before and after RF ablation and then up to postoperative day 7. In group 4 (N = 10), we sampled peripheral venous blood during diagnostic electrophysiologic study. The NGF concentration was determined by enzyme-linked immunosorbent assay. Transcardiac NGF concentration was the difference in NGF concentrations between coronary sinus and aorta.There was no change in transcardiac NGF concentrations in groups 1 and 2. In group 3, the NGF level did not change significantly from before the procedure (17.10 +/- 15.80 ng/mL) to immediately after the procedure (14.46 +/- 10.36 ng/mL). However, NGF levels increased significantly to 31.24 +/- 19.82 ng/mL (N = 21, P.0001) on postoperative day 1, 26.23 +/- 16.89 ng/mL (N = 20, P.001) on postoperative day 2, and 22.01 +/- 11.35 ng/mL (N = 16, P = .003) on postoperative day 3. NGF concentrations did not change significantly in group 4.RF ablation did not result in a detectable increase of transcardiac NGF concentration immediately after the procedure. However, the systemic NGF concentration increased significantly on postoperative days 1 to 3, suggesting that RF ablation resulted in increased NGF expression.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Enzyme-Linked Immunosorbent Assay
Catheter ablation
Femoral artery
Great cardiac vein
Recurrence
Physiology (medical)
medicine.artery
Internal medicine
Atrial Fibrillation
Nerve Growth Factor
medicine
Humans
Coronary sinus
Aorta
business.industry
Atrial fibrillation
Venous blood
Middle Aged
Prognosis
medicine.disease
Coronary Vessels
Femoral Artery
Endocrinology
Nerve growth factor
nervous system
Catheter Ablation
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 15475271
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Heart Rhythm
- Accession number :
- edsair.doi.dedup.....07ac669801a9ecb9286cfe0e914d20d5