Back to Search
Start Over
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting
- Source :
- Cell, Cell, Elsevier, 2017, 171 (1), pp.34-57. ⟨10.1016/j.cell.2017.08.002⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recently, they have been shown to globally control a plethora of cellular processes. This functional diversity is achieved by their ability to regulate chromatin at multiple levels, ranging from modifying local chromatin structure to orchestrating the three-dimensional organization of the genome. Understanding this system is a fascinating challenge of critical relevance for biology and medicine, since misexpression or mutation of multiple PcG components, as well as of TrxG members of the COMPASS family and of the SWI/SNF complex, is implicated in cancer and other diseases.
- Subjects :
- 0301 basic medicine
animal structures
Chromosomal Proteins, Non-Histone
Polycomb-Group Proteins
macromolecular substances
Biology
cellular memory
Genome
History, 21st Century
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Functional diversity
Neoplasms
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Gene expression
Genome regulation
Animals
Humans
cancer
trithorax
Epigenetics
development
Embryonic Stem Cells
Genetics
epigenetics
fungi
History, 20th Century
3. Good health
Chromatin
nuclear architecture
030104 developmental biology
Gene Expression Regulation
transgenerational epigenetic inheritance
chromatin
PRC1
transcription
polycomb
Subjects
Details
- Language :
- English
- ISSN :
- 00928674 and 10974172
- Database :
- OpenAIRE
- Journal :
- Cell, Cell, Elsevier, 2017, 171 (1), pp.34-57. ⟨10.1016/j.cell.2017.08.002⟩
- Accession number :
- edsair.doi.dedup.....07aad1f9c5dc2fd928ef7d59436b0a82