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Octreotide therapy for control of acute gastrointestinal bleeding in children
- Source :
- Journal of pediatric gastroenterology and nutrition. 38(1)
- Publication Year :
- 2003
-
Abstract
- Objectives To evaluate the outcomes of octreotide use in children with gastrointestinal bleeding with or without portal hypertension. Methods The medical charts of children who received continuous octreotide infusion for the indication of gastrointestinal bleeding from January 1995 to December 2000 were retrospectively reviewed. Results Twenty-one children with portal hypertension received octreotide infusions (1–2 μg/kg/h) during 35 gastrointestinal bleeding episodes. The duration of infusion ranged from 19 hours to 7 days. Bleeding ceased in 71% of children. Post-treatment rebleeding occurred in 52%, and the mortality was 19%. Response to octreotide, rebleeding, and mortality did not differ significantly between patients with or without intrinsic liver disease. Results Twelve children with gastrointestinal bleeding unrelated to portal hypertension received octreotide during 14 episodes. The duration of octreotide ranged from 3 hours to 36 days. Fifty percent of children had resolution of bleeding during the infusion. Post-treatment rebleeding occurred in 29%, and the mortality was 50%. No major adverse events were observed in either group. Conclusions A high rate of bleeding control was achieved with octreotide during acute gastrointestinal bleeding in children with portal hypertension. However, controlled studies are needed for more definitive description of its clinical effects. The role of octreotide is less clear in gastrointestinal bleeding unrelated to portal hypertension.
- Subjects :
- Adult
Male
Gastrointestinal bleeding
medicine.medical_specialty
Adolescent
Octreotide
Gastroenterology
Hemostatics
Liver disease
Gastrointestinal Agents
Recurrence
Internal medicine
Hypertension, Portal
medicine
Humans
Adverse effect
Child
Infusions, Intravenous
Retrospective Studies
business.industry
Acute gastrointestinal bleeding
Infant
Retrospective cohort study
medicine.disease
Treatment Outcome
El Niño
Child, Preschool
Pediatrics, Perinatology and Child Health
Acute Disease
Portal hypertension
Female
business
Gastrointestinal Hemorrhage
medicine.drug
Subjects
Details
- ISSN :
- 02772116
- Volume :
- 38
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of pediatric gastroenterology and nutrition
- Accession number :
- edsair.doi.dedup.....07a8affb265191340b5ad35947f178de