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The adventitia, endothelium and atherosclerosis
- Source :
- International journal of microcirculation, clinical and experimental. 17(5)
- Publication Year :
- 1997
-
Abstract
- Despite many theories, the initiating circumstances for the development of atherosclerosis remain obscure. The development of animal models of atherosclerosis was based upon the different theories of the origins of atherosclerosis which suggested that it originates at the intimal surface of the vessel. A more recent model of atherosclerosis involves perivascular manipulation of the vessel by positioning of a hollow silastic collar around the artery. In this model, several of the features seen in early human atherosclerosis are generated within a period of 7 days. It is hypothesized that arterial wall hypoxia following occlusion of the vasa vasorum may be the initial lesion of atherosclerosis, and hence that in some cases atherosclerosis is a disease of the outer layers of the arterial wall.
- Subjects :
- medicine.medical_specialty
Platelet-derived growth factor
Endothelium
Physiology
Arteriosclerosis
Vasa Vasorum
Hypoxia (medical)
Biology
Vascular endothelial growth factor
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
Internal medicine
Low-density lipoprotein
Vasa vasorum
Adventitia
medicine
Cardiology
Animals
Humans
Endothelium, Vascular
medicine.symptom
Cardiology and Cardiovascular Medicine
Artery
Subjects
Details
- ISSN :
- 01676865
- Volume :
- 17
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- International journal of microcirculation, clinical and experimental
- Accession number :
- edsair.doi.dedup.....07a0e86d4017dd309ec90e17e47933f3