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Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
- Source :
- Journal of Skin Cancer, Vol 2013 (2013), Journal of Skin Cancer
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Studies using keratinocyte-specific Stat3-deficient mice have revealed that Stat3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth. Use of both constitutive and inducible keratinocyte-specific Stat3-deficient mouse models has demonstrated that Stat3 is required for both the initiation and promotion stages of multistage skin carcinogenesis. Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. Studies using similar Stat3-deficient and gain-of-function mouse models have indicated its similar roles in ultraviolet B (UVB) radiation-mediated skin carcinogenesis. This paper summarizes the use of these various mouse models for studying the role and underlying mechanisms for the function of Stat3 in skin carcinogenesis. Given its significant role throughout the skin carcinogenesis process, Stat3 is an attractive target for skin cancer prevention and treatment.
- Subjects :
- Genetically modified mouse
Review Article
Dermatology
Biology
medicine.disease_cause
Bioinformatics
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
medicine
Keratinocyte migration
STAT3
Transcription factor
030304 developmental biology
0303 health sciences
integumentary system
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Hair follicle
3. Good health
Cell biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
STAT protein
biology.protein
Carcinogenesis
Wound healing
Subjects
Details
- ISSN :
- 20902913 and 20902905
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- Journal of Skin Cancer
- Accession number :
- edsair.doi.dedup.....079d4c2bbe7e221f2dbc2d169038fe52
- Full Text :
- https://doi.org/10.1155/2013/684050