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Hamster-Adapted Sin Nombre Virus Causes Disseminated Infection and Efficiently Replicates in Pulmonary Endothelial Cells without Signs of Disease

Authors :
Heinz Feldmann
Joseph Prescott
David Safronetz
Hideki Ebihara
Elaine Haddock
Dana P. Scott
Source :
Journal of Virology. 87:4778-4782
Publication Year :
2013
Publisher :
American Society for Microbiology, 2013.

Abstract

To date, a laboratory animal model for the study of Sin Nombre virus (SNV) infection or associated disease has not been described. Unlike infection with Andes virus, which causes lethal hantavirus pulmonary syndrome (HPS)-like disease in hamsters, SNV infection is short-lived, with no viremia and little dissemination. Here we investigated the effect of passaging SNV in hamsters. We found that a host-adapted SNV achieves prolonged and disseminated infection in hamsters, including efficient replication in pulmonary endothelial cells, albeit without signs of disease.

Details

ISSN :
10985514 and 0022538X
Volume :
87
Database :
OpenAIRE
Journal :
Journal of Virology
Accession number :
edsair.doi.dedup.....0796a99643d6d339259e7158197a3ef5
Full Text :
https://doi.org/10.1128/jvi.03291-12