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Hamster-Adapted Sin Nombre Virus Causes Disseminated Infection and Efficiently Replicates in Pulmonary Endothelial Cells without Signs of Disease
- Source :
- Journal of Virology. 87:4778-4782
- Publication Year :
- 2013
- Publisher :
- American Society for Microbiology, 2013.
-
Abstract
- To date, a laboratory animal model for the study of Sin Nombre virus (SNV) infection or associated disease has not been described. Unlike infection with Andes virus, which causes lethal hantavirus pulmonary syndrome (HPS)-like disease in hamsters, SNV infection is short-lived, with no viremia and little dissemination. Here we investigated the effect of passaging SNV in hamsters. We found that a host-adapted SNV achieves prolonged and disseminated infection in hamsters, including efficient replication in pulmonary endothelial cells, albeit without signs of disease.
- Subjects :
- Sin Nombre virus
viruses
Immunology
Andes virus
Adaptation, Biological
Hamster
Viremia
Disease
Hantavirus Pulmonary Syndrome
Biology
Virus Replication
Microbiology
Animal model
Cricetinae
Virology
medicine
Animals
Hantavirus pulmonary syndrome
Endothelial Cells
medicine.disease
Disease Models, Animal
Viral replication
Insect Science
Asymptomatic Diseases
Pathogenesis and Immunity
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....0796a99643d6d339259e7158197a3ef5
- Full Text :
- https://doi.org/10.1128/jvi.03291-12