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EuroTracker® dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging
- Source :
- Dalton transactions, 2015, Vol.44(11), pp.4791-4803 [Peer Reviewed Journal]
- Publication Year :
- 2014
-
Abstract
- The development of the brightest luminescent europium(III) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the most suitable strongly absorbing chromophore. Strategies for the synthesis of the complexes, including enantiopure analogues, are outlined and opportunities for applications in time-resolved microscopy and spectral imaging emphasised. Practicable examples are introduced, including selective organelle staining for cellular optical imaging at 65 nm resolution and the development of new bioassays using time-resolved FRET methods.
- Subjects :
- medicine.medical_specialty
Materials science
chemistry.chemical_element
Nanotechnology
Chemistry Techniques, Synthetic
010402 general chemistry
01 natural sciences
Inorganic Chemistry
Europium
Microscopy
medicine
Organometallic Compounds
Animals
Humans
Coloring Agents
010405 organic chemistry
Resolution (electron density)
Optical Imaging
Chromophore
Combinatorial chemistry
0104 chemical sciences
Spectral imaging
Förster resonance energy transfer
Enantiopure drug
chemistry
Biological Assay
Luminescence
Subjects
Details
- ISSN :
- 14779234
- Volume :
- 44
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Accession number :
- edsair.doi.dedup.....0790152c4b9c275d869b0b87c256cf99