Back to Search
Start Over
Incidence of chemotherapy-induced amenorrhea in premenopausal patients with breast cancer following adjuvant anthracycline and taxane
- Source :
- Breast Cancer. 18:182-188
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- The purpose of this study was to determine the incidence of amenorrhea among breast cancer patients aged 40 years and younger following adjuvant chemotherapy.A follow-up questionnaire survey was conducted with premenopausal women with breast cancer who were treated with adjuvant anthracycline and taxane-based chemotherapy.In total, 66 women were retrospectively reviewed. Forty-nine patients were treated with a regimen containing anthracycline followed by taxane and 17 patients with anthracycline alone. Fifty-eight patients (87.9%) experienced amenorrhea during chemotherapy; 14 patients (21.2%) had persistent amenorrhea after chemotherapy. The incidence of amenorrhea during chemotherapy and persistent amenorrhea was higher in patients older than 36 than in younger patients (97.9 vs. 63.2%, 27.7 vs. 5.3%). Additional taxane resulted in a higher incidence of amenorrhea compared with anthracycline-containing regimen alone (93.9 vs. 70.6%). Multivariate analysis showed that age (≥36 years) was independently associated with the incidences of amenorrhea during chemotherapy (p = 0.007).Age was the strongest predictor of the incidence of amenorrhea during chemotherapy. It is unclear whether additional taxane may contribute to amenorrhea. This information could be useful in deciding whether to use adjuvant chemotherapy.
- Subjects :
- Adult
Bridged-Ring Compounds
Oncology
endocrine system
medicine.medical_specialty
endocrine system diseases
Anthracycline
medicine.medical_treatment
Breast Neoplasms
Breast cancer
Surgical oncology
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Anthracyclines
Pharmacology (medical)
Radiology, Nuclear Medicine and imaging
Amenorrhea
Retrospective Studies
Chemotherapy
Taxane
business.industry
Incidence (epidemiology)
General Medicine
medicine.disease
Chemotherapy, Adjuvant
Multivariate Analysis
Female
Taxoids
medicine.symptom
business
Adjuvant
Subjects
Details
- ISSN :
- 18804233 and 13406868
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Breast Cancer
- Accession number :
- edsair.doi.dedup.....0787f26b7115552d5ed556d1cbc0a195