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The role of cell-free circulating microRNA in diagnostics in patients with rheumatoid arthritis

Authors :
Agnieszka Paradowska-Gorycka
Barbara Stypinska
Source :
Rheumatology, Vol 54, Iss 3, Pp 95-96 (2016), Reumatologia
Publication Year :
2016
Publisher :
Termedia Publishing House, 2016.

Abstract

Rheumatoid arthritis (RA) is a systemic, autoimmune disease, which is characterized by inflammation and progressive destruction of the synovial joints leading to pain, long term disability, and reduced quality of life in many patients. Human genetic and epidemiology studies have shown that causal factors of disease include pre-determined contributions from at least 40 different genes and the effect of environmental factors. Epigenetic represent a new aspect in autoimmunity, which refers to changes in gene expression that do not involve changes in DNA sequence. Recently, the list of molecules important for RA pathogenesis has been extended by microRNAs (miRNAs), which play a key role in regulating both adaptive and innate immune response, development and differentiation of immune cells, and the prevention of autoimmunity.

Details

Language :
English
ISSN :
20849834 and 00346233
Volume :
54
Issue :
3
Database :
OpenAIRE
Journal :
Rheumatology
Accession number :
edsair.doi.dedup.....0782a69d983df722fd14dc905ccae4f0