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The role of cell-free circulating microRNA in diagnostics in patients with rheumatoid arthritis
- Source :
- Rheumatology, Vol 54, Iss 3, Pp 95-96 (2016), Reumatologia
- Publication Year :
- 2016
- Publisher :
- Termedia Publishing House, 2016.
-
Abstract
- Rheumatoid arthritis (RA) is a systemic, autoimmune disease, which is characterized by inflammation and progressive destruction of the synovial joints leading to pain, long term disability, and reduced quality of life in many patients. Human genetic and epidemiology studies have shown that causal factors of disease include pre-determined contributions from at least 40 different genes and the effect of environmental factors. Epigenetic represent a new aspect in autoimmunity, which refers to changes in gene expression that do not involve changes in DNA sequence. Recently, the list of molecules important for RA pathogenesis has been extended by microRNAs (miRNAs), which play a key role in regulating both adaptive and innate immune response, development and differentiation of immune cells, and the prevention of autoimmunity.
- Subjects :
- 030203 arthritis & rheumatology
Regulation of gene expression
Epigenetic regulation of neurogenesis
Immunology
lcsh:R
lcsh:Medicine
Computational biology
Biology
Bioinformatics
Editorial Paper
Chromatin
03 medical and health sciences
0302 clinical medicine
Histone
Rheumatology
DNA methylation
microRNA
biology.protein
Immunology and Allergy
Nucleosome
Epigenetics
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 20849834 and 00346233
- Volume :
- 54
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Rheumatology
- Accession number :
- edsair.doi.dedup.....0782a69d983df722fd14dc905ccae4f0