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WHO classification of alveolar echinococcosis: principles and application
- Source :
- Parasitology International, Parasitology International, Elsevier, 2006, 55 Suppl, pp.S283-287. ⟨10.1016/j.parint.2005.11.041⟩, Parasitology International, Elsevier, 2006, 55 Suppl, pp.S283-287. 〈10.1016/j.parint.2005.11.041〉
- Publication Year :
- 2006
- Publisher :
- HAL CCSD, 2006.
-
Abstract
- International audience; Alveolar echinococcosis is caused by the larval stage of the fox tapeworm (Echinococcus multilocularis) and is frequently diagnosed as a space occupying lesion in the liver. The growth pattern resembles that of a malignant tumor with infiltration throughout the liver, spreading into neighbouring organs and metastases formation in distant organs. Thus, one of the prevailing differential diagnoses is liver cancer. Guided by the Tumor-Node-Metastasis (TNM) system of liver cancer, the European Network for Concerted Surveillance of Alveolar Echinococcosis and the WHO Informal Working Group on Echinococcosis proposed a clinical classification for alveolar echinococcosis. It was designated as PNM system (P = parasitic mass in the liver, N = involvement of neighbouring organs, and M = metastasis). As for TNM in oncology, single PNM categories were combined into four stages, I to IV. The system was developed by a retrospective analysis of 97 patients' records from two treatment centers (Besançon/France and Ulm/Germany). Recently, this WHO classification was applied to 222 patients in 4 clinical centers around the world (Besançon/France, n = 26; Urumqi/China, n = 46; Sapporo/Japan, n = 58; and Ulm/Germany, n = 92). All patients could be classified who had been diagnosed in the period from January 1998 to June 2005. The stage grouping indicated center differences, but appeared to segregate patients according to various treatment regimens. The WHO classification not only serves as a tool for the international standardization of disease manifestation but also aids to evaluate the outcome of a chosen diagnostic and treatment procedure in different treatment centers in Europe and Asia.
- Subjects :
- Echinococcosis, Hepatic
Pathology
medicine.medical_specialty
030231 tropical medicine
Foxes
Alveolar echinococcosis
MESH : Echinococcus multilocularis
World Health Organization
Echinococcus multilocularis
MESH: World Health Organization
Metastasis
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Humans
MESH: Animals
[ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
MESH : Foxes
MESH: Echinococcus multilocularis
MESH: Foxes
MESH: Humans
biology
business.industry
MESH : Humans
MESH: Echinococcosis, Hepatic
MESH : Liver
medicine.disease
biology.organism_classification
Echinococcosis
3. Good health
Infectious Diseases
Liver
030211 gastroenterology & hepatology
Parasitology
MESH : Animals
MESH : World Health Organization
Treatment procedure
Who classification
Disease manifestation
business
Liver cancer
MESH : Echinococcosis, Hepatic
MESH: Liver
Subjects
Details
- Language :
- English
- ISSN :
- 13835769
- Database :
- OpenAIRE
- Journal :
- Parasitology International, Parasitology International, Elsevier, 2006, 55 Suppl, pp.S283-287. ⟨10.1016/j.parint.2005.11.041⟩, Parasitology International, Elsevier, 2006, 55 Suppl, pp.S283-287. 〈10.1016/j.parint.2005.11.041〉
- Accession number :
- edsair.doi.dedup.....076a00b73baad1c525028ec8b3b7d2f4