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The Dutch-Belgian Registry of Stereotactic Body Radiation Therapy for Liver Metastases: Clinical Outcomes of 515 Patients and 668 Metastases
- Source :
- International Journal of Radiation Oncology, Biology, Physics, 109, 5, pp. 1377-1386, International Journal of Radiation Oncology, Biology, Physics, 109, 1377-1386, Méndez Romero, A, Schillemans, W, van Os, R, Koppe, F, Haasbeek, C J, Hendriksen, E M, Muller, K, Ceha, H M, Braam, P T M, Reerink, O, Intven, M P M, Joye, I, Jansen, E P M, Westerveld, H, Koedijk, M S, Heijmen, B J M & Buijsen, J 2021, ' The Dutch–Belgian Registry of Stereotactic Body Radiation Therapy for Liver Metastases: Clinical Outcomes of 515 Patients and 668 Metastases ', International Journal of Radiation Oncology Biology Physics, vol. 109, no. 5, pp. 1377-1386 . https://doi.org/10.1016/j.ijrobp.2020.11.045, International Journal of Radiation Oncology Biology Physics, 109(5), 1377-1386. Elsevier Inc.
- Publication Year :
- 2021
-
Abstract
- Contains fulltext : 232797.pdf (Publisher’s version ) (Open Access) PURPOSE: Although various studies have reported that stereotactic body radiation therapy (SBRT) for liver metastases has high local control rates and relatively low toxicity, most series included a small number of patients. We aimed to validate these outcomes in a large multi-institution patient cohort treated in accordance with a common protocol. METHODS AND MATERIALS: A shared web-based registry of patients with liver metastases treated with SBRT was developed by 13 centers (12 in the Netherlands and 1 in Belgium). All the centers had previously agreed on the items to be collected, the fractionation schemes, and the organs-at-risk constraints to be applied. Follow-up was performed at the discretion of the centers. Patient, tumor, and treatment characteristics were entered in the registry. Only liver metastases treated individually as independent targets and with at least 1 radiologic follow-up examination were considered for local control analysis. Toxicity of grade 3 or greater was scored according to the Common Terminology Criteria of Adverse Events (v4.03). RESULTS: Between January 1, 2013, and July 31, 2019, a total of 515 patients were entered in the web-based registry. The median age was 71 years. In total, 668 liver metastases were registered, and 447 were included for local control analysis. The most common primary tumor origin was colorectal cancer (80.3%), followed by lung cancer (8.9%) and breast cancer (4%). The most-used fractionation scheme was 3x18-20 Gy (36.0%), followed by 8x7.5 Gy (31.8%), 5x11-12 Gy (25.5%), and 12x5 Gy (6.7%). The median follow-up time was 1.1 years for local control and 2.3 years for survival. Actuarial 1-year local control was 87%; 1-year overall survival was 84%. Toxicity of grade 3 or greater was found in 3.9% of the patients. CONCLUSIONS: This multi-institutional study confirms the high rates of local control and limited toxicity in a large patient cohort. Stereotactic body radiation therapy should be considered a valuable part of the multidisciplinary approach to treating liver metastases.
- Subjects :
- Adult
Male
Organs at Risk
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Time Factors
Stereotactic body radiation therapy
Colorectal cancer
Breast Neoplasms
Kaplan-Meier Estimate
Radiosurgery
030218 nuclear medicine & medical imaging
03 medical and health sciences
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
Breast cancer
Belgium
SDG 3 - Good Health and Well-being
Stomach Neoplasms
medicine
Humans
Radiology, Nuclear Medicine and imaging
Registries
Adverse effect
Lung cancer
Radiation Injuries
Aged
Netherlands
Aged, 80 and over
Radiation
business.industry
Liver Neoplasms
Stomach
Gallbladder
Middle Aged
medicine.disease
Primary tumor
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Toxicity
Cohort
Female
Radiology
Dose Fractionation, Radiation
business
Colorectal Neoplasms
Follow-Up Studies
Subjects
Details
- ISSN :
- 03603016
- Database :
- OpenAIRE
- Journal :
- International Journal of Radiation Oncology, Biology, Physics, 109, 5, pp. 1377-1386, International Journal of Radiation Oncology, Biology, Physics, 109, 1377-1386, Méndez Romero, A, Schillemans, W, van Os, R, Koppe, F, Haasbeek, C J, Hendriksen, E M, Muller, K, Ceha, H M, Braam, P T M, Reerink, O, Intven, M P M, Joye, I, Jansen, E P M, Westerveld, H, Koedijk, M S, Heijmen, B J M & Buijsen, J 2021, ' The Dutch–Belgian Registry of Stereotactic Body Radiation Therapy for Liver Metastases: Clinical Outcomes of 515 Patients and 668 Metastases ', International Journal of Radiation Oncology Biology Physics, vol. 109, no. 5, pp. 1377-1386 . https://doi.org/10.1016/j.ijrobp.2020.11.045, International Journal of Radiation Oncology Biology Physics, 109(5), 1377-1386. Elsevier Inc.
- Accession number :
- edsair.doi.dedup.....075ce2c8c7f8506266a7d55249281430