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A High Viral Burden Predicts the Loss of CD8 T-Cell Responses Specific for Subdominant Gag Epitopes during Chronic Human Immunodeficiency Virus Infection
- Source :
- Journal of Virology. 81:13809-13815
- Publication Year :
- 2007
- Publisher :
- American Society for Microbiology, 2007.
-
Abstract
- Human immunodeficiency virus (HIV)-specific CD8 T-cell responses targeting products encoded within the Gag open reading frame have frequently been associated with better viral control and disease outcome during the chronic phase of HIV infection. To further clarify this relationship, we have studied the dynamics of Gag-specific CD8 T-cell responses in relation to plasma viral load and time since infection in 33 chronically infected subjects over a 9-month period. High baseline viral loads were associated with a net loss of breadth (P< 0.001) and a decrease in the total magnitude of the Gag-specific T-cell response in general (P= 0.03). Most importantly, the baseline viral load predicted the subsequent change in the breadth of Gag recognition over time (P< 0.0001,r2= 0.41). Compared to maintained responses, lost responses were low in magnitude (P< 0.0001) and subdominant in the hierarchy of Gag-specific responses. The present study indicates that chronic exposure of the human immune system to high levels of HIV viremia is a determinant of virus-specific CD8 T-cell loss.
- Subjects :
- Cellular immunity
Subdominant
viruses
Immunology
Gene Products, gag
HIV Infections
Viremia
CD8-Positive T-Lymphocytes
Microbiology
Virus
Cohort Studies
Epitopes
Predictive Value of Tests
Virology
Immunopathology
medicine
Humans
biology
Viral Load
biology.organism_classification
medicine.disease
CD4 Lymphocyte Count
Insect Science
Chronic Disease
Lentivirus
HIV-1
Pathogenesis and Immunity
RNA, Viral
Female
Viral disease
Viral load
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....07528e081b7687d05b2d6703e8ce1c96