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Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists
- Source :
- Bioorganic & Medicinal Chemistry Letters. 19:1431-1433
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- A series of potent and orally bioavailable 3,4-diaminocyclobutenediones with various fluoroalkyl groups as alpha side chain were prepared and found to show significant improvements in the binding affinities towards both CXCR2 and CXCR1 receptors.
- Subjects :
- Binding Sites
Stereochemistry
Chemistry
Organic Chemistry
Clinical Biochemistry
Administration, Oral
Pharmaceutical Science
Alpha (ethology)
Plasma protein binding
Biochemistry
Receptors, Interleukin-8B
Rats
Receptors, Interleukin-8A
Bioavailability
Drug Discovery
Side chain
Animals
Molecular Medicine
CXC chemokine receptors
Binding site
Receptor
Molecular Biology
Cyclobutanes
Protein Binding
Binding affinities
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....07506e5dcc6c2c3c8a81a1e401461e78
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.01.033