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Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease
- Publication Year :
- 2019
- Publisher :
- Cold Spring Harbor Laboratory, 2019.
-
Abstract
- To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we conducted a large-scale genome-wide association study (GWAS) of 168,228 Japanese (25,892 cases and 142,336 controls) with genotype imputation using a newly developed reference panel of Japanese haplotypes including 1,782 CAD cases and 3,148 controls. We detected 9 novel disease-susceptibility loci and Japanese-specific rare variants contributing to disease severity and increased cardiovascular mortality. We then conducted a transethnic meta-analysis and discovered 37 additional novel loci. Using the result of the meta-analysis, we derived a polygenic risk score (PRS) for CAD, which outperformed those derived from either Japanese or European GWAS. The PRS prioritized risk factors among various clinical parameters and segregated individuals with increased risk of long-term cardiovascular mortality. Our data improves clinical characterization of CAD genetics and suggests the utility of transethnic meta-analysis for PRS derivation in non-European populations.
- Subjects :
- Genetics
0303 health sciences
Haplotype
Genome-wide association study
030204 cardiovascular system & hematology
Biology
medicine.disease
Genome
3. Good health
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Increased risk
Disease severity
Population specific
medicine
030304 developmental biology
Cardiovascular mortality
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....073aa4439f188aa494afdf859ad02943
- Full Text :
- https://doi.org/10.1101/827550