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Identification of Monotonically Differentially Expressed Genes for IFN-β-Treated Multiple Sclerosis Patients
- Source :
- BioMed Research International, BioMed Research International, Vol 2019 (2019)
- Publication Year :
- 2019
- Publisher :
- Hindawi, 2019.
-
Abstract
- Multiple sclerosis (MS) is a common neurological disability of the central nervous system. Immune-modulatory therapy with interferon-β (IFN-β) has been used as a first-line treatment to prevent relapses in MS patients. While the therapeutic mechanism of IFN-β has not been fully elucidated, the data of microarray experiments that collected longitudinal gene expression profiles to evaluate the long-term response of IFN-β treatment have been analyzed using statistical methods that were incapable of dealing with such data. In this study, the GeneRank method was applied to generate weighted gene expression values and the monotonically expressed genes (MEGs) for both IFN-β treatment responders and nonresponders were identified. The proposed procedure identified 13 MEGs for the responders and 2 MEGs for the nonresponders, most of which are biologically relevant to MS. Our work here provides some useful insight into the mechanism of IFN-β treatment for MS patients. A full understanding of the therapeutic mechanism will enable a more personalized treatment strategy possible.
- Subjects :
- Male
Multiple Sclerosis
Article Subject
Microarray
Central nervous system
lcsh:Medicine
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
Gene expression
Humans
Immunologic Factors
Medicine
Gene
General Immunology and Microbiology
business.industry
Mechanism (biology)
Gene Expression Profiling
Multiple sclerosis
lcsh:R
Interferon-beta
General Medicine
medicine.disease
Gene expression profiling
Cross-Sectional Studies
Differentially expressed genes
medicine.anatomical_structure
Female
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....0735067e1b69ba18d891642506569b68