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High dropout rate from aftercare program of antihepatitis C therapy for patients with history of injection drug use
- Source :
- JGH Open, Vol 4, Iss 5, Pp 964-969 (2020), JGH Open: An Open Access Journal of Gastroenterology and Hepatology
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background and Aim We assessed direct‐acting antiviral (DAA) treatment for patients with hepatitis C virus (HCV) and a history of injection drug use (IDU) in Japan. Method This retrospective observational study was based on clinical records. Overall, 804 DAA‐naïve HCV‐infected patients were enrolled, treated with a 12‐week regimen of DAAs, and had available information about a history of IDU. Anti‐HCV efficacy was defined as a sustained viral response 12 weeks post‐treatment (SVR12) only in patients who were assessed after 12 weeks [modified intention‐to‐treat (ITT) analyses]. We compared the antiviral effect between patients with (past‐IDU) and without a history of IDU (non‐IDU). We also evaluated the characteristics of each group, including the overall dropout rate and economic background. Results Overall, 78 (9.7%) patients had a history of IDU. Compared to the non‐IDU group at baseline, the past‐IDU group consisted of predominantly male and younger patients infected with HCV genotype 2. Overall, 3% (3/78) and 16% (116/726) of the patients had cirrhosis in the past‐IDU and non‐IDU group, respectively. There was a significantly higher rate of welfare recipients in the past‐IDU group. SVR rate was 97% (59/61) in the past‐IDU group and 99% (689/699) in the non‐IDU group. The cumulative rate of dropout from an aftercare program was high in the past‐IDU group (P<br />The cumulative dropout rates from the aftercare program of antihepatitis C therapy were significantly higher in the past‐IDU group compared to those in the non‐IDU group (P
- Subjects :
- hepatitis C virus
medicine.medical_specialty
Cirrhosis
Hepatitis C virus
Dropout (communications)
person who injecting drugs
RC799-869
medicine.disease_cause
dropout
Injection drug use
03 medical and health sciences
0302 clinical medicine
injection drug use
immune system diseases
Internal medicine
mental disorders
Medicine
Sustained viral response
In patient
Hepatology
business.industry
direct‐acting antivirals
Gastroenterology
virus diseases
Retrospective cohort study
Original Articles
social sciences
Diseases of the digestive system. Gastroenterology
medicine.disease
Regimen
030220 oncology & carcinogenesis
Original Article
030211 gastroenterology & hepatology
business
Subjects
Details
- Language :
- English
- ISSN :
- 23979070
- Volume :
- 4
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- JGH Open
- Accession number :
- edsair.doi.dedup.....072ef0cd910a0ebf0606197cf108853c