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A fresh look at IBS-opportunities for systems medicine approaches
A fresh look at IBS-opportunities for systems medicine approaches
- Source :
- Neurogastroenterology and motility, 29(3):e12989. Wiley-Blackwell, Journal of Neurogastroenterology and Motility, Journal of Neurogastroenterology and Motility, Korean Society of Neurogastroenterology and Motility, 2017, 29 (3), ⟨10.1111/nmo.12989⟩
- Publication Year :
- 2017
-
Abstract
- International audience; NeuroGUT is a EU-funded initial training network (ITN) of 14 research projects in neurogastroenterology that have employed an equal number of early-stage researchers. Neurogut trainees haveamong other activitiesattended an international conference on irritable bowel syndrome (IBS) in Bologna in 2016 and were asked to critically review and evaluate the current knowledge on IBS for their respective research activities, and to state what they were missing. Most appreciated were the topics brain imaging of gut activity, the role of the gut microbiota, the pharmacology of gut functions, the IBS-IBD interrelation, the new Rome IV criteria, the role of gas, and the placebo response in functional disorders. Missed were more detailed coverage of high-resolution manometry, functional brain imaging, advanced systems medicine approaches and bioinformatics technology, better sub-classification of IBS patients, and the development of disease biomarkers, extended at the molecular (genetic/epigenetic, proteonomic) level. They summarize that despite excellent specialized research, there is a gap open that should be filled with systems medicine. For this, it would be necessary that medical research learns even more from the data sciences and other basic disciplines, for example, information technology and system biology, and also welcomes a change in paradigm that enhances open sharing of data, information, and resources.
- Subjects :
- medicine.medical_specialty
Biomedical Research
Systems Analysis
Physiology
[SDV]Life Sciences [q-bio]
Systems biology
Alternative medicine
Gastroenterology
Endocrine and Autonomic System
03 medical and health sciences
0302 clinical medicine
Neuroimaging
Internal medicine
medicine
Humans
Education, Graduate
European Union
Irritable bowel syndrome
irritable bowel syndrome
Medical education
Endocrine and Autonomic Systems
business.industry
Information technology
Neurogastroenterology
Medical research
medicine.disease
functional bowel disorders
3. Good health
functional bowel disorder
Systems medicine
030211 gastroenterology & hepatology
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 13501925, 20930879, and 20930887
- Database :
- OpenAIRE
- Journal :
- Neurogastroenterology and motility, 29(3):e12989. Wiley-Blackwell, Journal of Neurogastroenterology and Motility, Journal of Neurogastroenterology and Motility, Korean Society of Neurogastroenterology and Motility, 2017, 29 (3), ⟨10.1111/nmo.12989⟩
- Accession number :
- edsair.doi.dedup.....072d80e1de2e0acff34ef5de072048a9
- Full Text :
- https://doi.org/10.1111/nmo.12989⟩