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A fresh look at IBS-opportunities for systems medicine approaches

A fresh look at IBS-opportunities for systems medicine approaches

Authors :
Ahmed Albusoda
Annikka V. Polster
Jasper B. J. Kamphuis
H. Wang
N. Barki
T. B. Karunaratne
M. Lazarou
T. V. K. Herregods
Eluisa Perna
T. Pribic
In-Seon Lee
Paul Enck
F. Uhlig
N. Mazurak
Graduate School
Gastroenterology and Hepatology
University of London
Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)
University of Amsterdam [Amsterdam] (UvA)
Institut National de la Recherche Agronomique (INRA)
Alma Mater Studiorum University of Bologna (UNIBO)
Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen
Symbio Pharm GmbH
Partenaires INRAE
Katholieke Univ Leuven
University of Gothenburg (GU)
Institut de Recerca
Vall d'Hebron University Hospital [Barcelona]
University of Sheffield
NeuroGUT
Albusoda, A.
Barki, N.
Herregods, T.
Kamphuis, J. B. J.
Karunaratne, TENNEKOON MUDIYANSELAGE PRASANTHA BUDDHIKA
Lazarou, M.
Lee, I.
Mazurak, N.
Perna, E.
Polster, A.
Pribic, T.
Uhlig, F.
Wang, H.
Enck, P.
Source :
Neurogastroenterology and motility, 29(3):e12989. Wiley-Blackwell, Journal of Neurogastroenterology and Motility, Journal of Neurogastroenterology and Motility, Korean Society of Neurogastroenterology and Motility, 2017, 29 (3), ⟨10.1111/nmo.12989⟩
Publication Year :
2017

Abstract

International audience; NeuroGUT is a EU-funded initial training network (ITN) of 14 research projects in neurogastroenterology that have employed an equal number of early-stage researchers. Neurogut trainees haveamong other activitiesattended an international conference on irritable bowel syndrome (IBS) in Bologna in 2016 and were asked to critically review and evaluate the current knowledge on IBS for their respective research activities, and to state what they were missing. Most appreciated were the topics brain imaging of gut activity, the role of the gut microbiota, the pharmacology of gut functions, the IBS-IBD interrelation, the new Rome IV criteria, the role of gas, and the placebo response in functional disorders. Missed were more detailed coverage of high-resolution manometry, functional brain imaging, advanced systems medicine approaches and bioinformatics technology, better sub-classification of IBS patients, and the development of disease biomarkers, extended at the molecular (genetic/epigenetic, proteonomic) level. They summarize that despite excellent specialized research, there is a gap open that should be filled with systems medicine. For this, it would be necessary that medical research learns even more from the data sciences and other basic disciplines, for example, information technology and system biology, and also welcomes a change in paradigm that enhances open sharing of data, information, and resources.

Details

Language :
English
ISSN :
13501925, 20930879, and 20930887
Database :
OpenAIRE
Journal :
Neurogastroenterology and motility, 29(3):e12989. Wiley-Blackwell, Journal of Neurogastroenterology and Motility, Journal of Neurogastroenterology and Motility, Korean Society of Neurogastroenterology and Motility, 2017, 29 (3), ⟨10.1111/nmo.12989⟩
Accession number :
edsair.doi.dedup.....072d80e1de2e0acff34ef5de072048a9
Full Text :
https://doi.org/10.1111/nmo.12989⟩