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A Stereological Study of the Mediodorsal Thalamic Nucleus in Down Syndrome
- Source :
- Neuroscience, 279, 253-259. Elsevier Limited, Karlsen, A S, Korbo, S, Uylings, H B M & Pakkenberg, B 2014, ' A Stereological Study of the Mediodorsal Thalamic Nucleus in Down Syndrome ', Neuroscience, vol. 279, pp. 253-259 . https://doi.org/10.1016/j.neuroscience.2014.08.046
- Publication Year :
- 2014
-
Abstract
- The total number of neurons and glial cells in the mediodorsal thalamic (MDT) nucleus of four aged females with Down syndrome (DS; mean age 69years) was estimated and compared to six age- and sex-matched controls. The MDT nucleus was delineated on coronal sections, and cell numbers (large and small neurons, oligodendrocytes, and astrocytes) were estimated using the optical fractionator technique. The DS brains had an average of 3.41×10(6) total neurons in the MDT nucleus in contrast to 5.97×10(6) in the controls, with no overlap (2p=0.004), affecting large (projecting) and small (local inhibitory) neurons nearly equally. In contrast, we observed no significant differences in either glial cell population. The cortical structures of the same four DS brains were previously estimated to be half the normal size of controls with a reduction in cell numbers whereas the basal ganglia were unaffected. As DS brains are affected by developmental delay, premature aging, and Alzheimer-like pathology, the finite cause of the reduced number of cells in MDT nucleus cannot be determined; however, these findings provide stereological evidence for a local reduction in neuron numbers in the MDT nucleus, which could affect the cognitive capacity of patients with DS.
- Subjects :
- Premature aging
Pathology
medicine.medical_specialty
Mediodorsal Thalamic Nucleus
Population
Thalamus
Cell Count
Biology
Inhibitory postsynaptic potential
Basal ganglia
medicine
Humans
education
Aged
Aged, 80 and over
Neurons
education.field_of_study
General Neuroscience
Anatomy
Organ Size
Middle Aged
medicine.anatomical_structure
Neuroglia
Female
Neuron
Down Syndrome
Nucleus
Subjects
Details
- ISSN :
- 03064522
- Database :
- OpenAIRE
- Journal :
- Neuroscience, 279, 253-259. Elsevier Limited, Karlsen, A S, Korbo, S, Uylings, H B M & Pakkenberg, B 2014, ' A Stereological Study of the Mediodorsal Thalamic Nucleus in Down Syndrome ', Neuroscience, vol. 279, pp. 253-259 . https://doi.org/10.1016/j.neuroscience.2014.08.046
- Accession number :
- edsair.doi.dedup.....0728b8b273367f8ad1c8990232b51e8b