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Cyclosporin A for persistent or chronic immune thrombocytopenia in children
- Source :
- Annals of hematology. 95(11)
- Publication Year :
- 2016
-
Abstract
- Twenty percent of children with immune thrombocytopenia (ITP) develop a chronic course where treatment strategy is less established. Cyclosporin A (CSA) has been shown to be effective in small series of children with chronic ITP and might reduce the need for chronic steroid therapy and/or splenectomy. We reviewed consecutive patients below 18 years old with persistent or chronic ITP treated with CSA in our unit between January 1998 and June 2015. Thirty patients (14 boys and 16 girls) were included. The median age at initial diagnosis of ITP was 5 years (range 0.5-16.2 years). CSA was started at a median of 13.9 months (range 3.4-124 months) after initial diagnosis and given for a median duration of 9.3 months (range 0.2-63.9 months). The median platelet count before commencement was 12 × 10(9)/L (range 4-199 × 10(9)/L). The median dose of CSA was 6 mg/kg/day (range 2.4-7.5 mg/kg/day). Complete response (CR) or response (R) was achieved in 17 patients (57 %), and 7 (23 %) had sustained response. Side effects (most commonly hirsutism) were tolerable and reversible. CSA appeared effective in about half of persistent or chronic ITP patients and safe as a second-line agent in managing these children.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Hirsutism
Adolescent
medicine.medical_treatment
Splenectomy
03 medical and health sciences
0302 clinical medicine
Cyclosporin a
Internal medicine
medicine
Humans
Child
hirsutism
Complete response
Retrospective Studies
Purpura, Thrombocytopenic, Idiopathic
Hematology
business.industry
Platelet Count
Remission Induction
Infant
General Medicine
medicine.disease
Immune thrombocytopenia
Steroid therapy
030220 oncology & carcinogenesis
Sustained response
Child, Preschool
Chronic Disease
Cyclosporine
Drug Evaluation
Female
business
Immunosuppressive Agents
030215 immunology
Subjects
Details
- ISSN :
- 14320584
- Volume :
- 95
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Annals of hematology
- Accession number :
- edsair.doi.dedup.....0728733202d4684bd7a6309ce1c28620