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Study of Spectrum of Chromosomal Rearrangements in Recurrent Pregnancy Loss
- Source :
- J Obstet Gynaecol India
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- INTRODUCTION: Recurrent pregnancy losses (RPLs) are seen in up to 15–20% of all clinically recognized pregnancies, 1–2% of women in general population. Repeated losses are seen in 5–10% of women. The prevalence of chromosomal rearrangements is 6.65% in couples with repeated pregnancy losses. Two to 4% of RPL are associated with parental balanced reciprocal and Robertsonian translocations. MATERIALS AND METHODS: The study was conducted at a tertiary care hospital in New Delhi, and in total, 204 couples with RPL enrolled in the study. RESULTS: In total, 4490 couples presented to the obstetric clinic, of which 204 (4.5%) couples had repeated pregnancy losses. Cytogenetic analysis was done in 198 couples. Out of total 198 patients, 14 patients (7.1%) had cytogenetic alterations. Most common aberrations observed were structural rearrangements, of which reciprocal translocations were more common. In our study cohort, all the couples had maternal age of ≤ 35 years and all the alterations were seen either in mother or in both parents. DISCUSSION: Our study highlights that cytogenetic alterations not only are common in first trimester miscarriages, but are an important event in miscarriages presenting at later period of gestation and in young mothers as well.
- Subjects :
- medicine.medical_specialty
Pregnancy
education.field_of_study
030219 obstetrics & reproductive medicine
Obstetrics
business.industry
Population
Obstetrics and Gynecology
Tertiary care hospital
medicine.disease
Miscarriage
03 medical and health sciences
First trimester
0302 clinical medicine
Cohort
medicine
Gestation
Original Article
New delhi
030212 general & internal medicine
business
education
Subjects
Details
- ISSN :
- 09756434 and 09719202
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- The Journal of Obstetrics and Gynecology of India
- Accession number :
- edsair.doi.dedup.....071f17f2b0fb8cdf0a0b962ffdd4c3e0