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C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection
- Source :
- Immunity. (2):324-334
- Publisher :
- Elsevier Inc.
-
Abstract
- SummaryC-type lectin receptors (CLRs) play critical roles as pattern-recognition receptors (PRRs) for sensing Candida albicans infection, which can be life-threatening for immunocompromised individuals. Here we have shown that Dectin-3 (also called CLECSF8, MCL, or Clec4d), a previously uncharacterized CLR, recognized α-mannans on the surfaces of C. albicans hyphae and induced NF-κB activation. Mice with either blockade or genetically deleted Dectin-3 were highly susceptible to C. albicans infection. Dectin-3 constantly formed heterodimers with Dectin-2, a well-characterized CLR, for recognizing C. albicans hyphae. Compared to their respective homodimers, Dectin-3 and Dectin-2 heterodimers bound α-mannans more effectively, leading to potent inflammatory responses against fungal infections. Together, our study demonstrates that Dectin-3 forms a heterodimeric PRR with Dectin-2 for sensing fungal infection and suggests that different CLRs may form different hetero- and homodimers, which provide different sensitivity and diversity for host cells to detect various microbial infections.
- Subjects :
- Hypha
Transgene
Immunology
Hyphae
Mice, Transgenic
Biology
Microbiology
Mannans
Enzyme activator
Mice
C-type lectin
Candida albicans
Immunology and Allergy
Animals
Humans
Lectins, C-Type
Receptor
Pattern recognition receptor
Candidiasis
NF-kappa B
Lectin
Membrane Proteins
Enzyme Activation
Mice, Inbred C57BL
Infectious Diseases
Receptors, Pattern Recognition
biology.protein
Female
Signal transduction
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....071dd61a98a14299e080b5b866f49d1c
- Full Text :
- https://doi.org/10.1016/j.immuni.2013.05.017